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Inhibitors of animal, plant, and microbial origin were tested against human and canine granulocytic elastases. The trypsin-chymotrypsin inhibitors from dog submandibular glands, from soybeans (Bowman-Birk) and from chickpeas show strong interaction with these proteases (Ki = 10(-8) - 10(-9)M). The trypsin-kallikrein inactivator of bovine organs (Trasylol) is not active against granulocytic elastases or against human granulocytic cathepsin G. Elastatinal, a specific inhibitor of elastases, isolated from actinomycetes (Streptomyces griseoruber), forms stable complexes with elastase from human (Ki = 6.2 X 10(-6)M) and canine granulocytes (Ki = 1.1 X 10(-6)M). A possible therapeutic application of these inhibitors for the inactivation of granulocytic proteases, which are able to degrade connective tissue in different pathological states, is discussed.
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
December 1975,
Scandinavian journal of clinical and laboratory investigation,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
January 1974,
Journal of biochemistry,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
February 1977,
The Journal of laboratory and clinical medicine,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
December 1974,
Scandinavian journal of clinical and laboratory investigation,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
January 1976,
Methods in enzymology,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
November 1968,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
April 2024,
American journal of veterinary research,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
March 1976,
Indian journal of biochemistry & biophysics,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
November 1970,
Blut,
H Schiessler, and
K Ohlsson, and
I Olsson, and
M Arnhold, and
Y Birk, and
H Fritz
March 1974,
European journal of biochemistry,
