-transparent.png){kind=logo}
The characteristics of the cytoskeleton of a Fischer rat embryo fibroblast cell line (3Y1) transformed by ultraviolet (UV)-irradiated HSV were studied by indirect immunofluorescence using anti-actin IgG. Parental 3Y1 cells possessed well-developed actin filaments, while 3Y1 cells transformed by UV-irradiated HSV also retained well-developed actin filaments. Transformed cells were divided into 2 groups according to tumorigenicity in newborn Fischer rats; one had a strongly tumorigenic potential and the other a weakly tumorigenic potential. Tumor-derived cell lines exhibited a highly tumorigenic potential, and were also divided into 2 groups, one with well-developed actin filaments and the other without well-developed actin filaments. Our results suggested that transformation or tumor formation by HSV is a multi-step process and that morphological loss of actin filaments in the cells is not essential to the tumorigenic potential of the cells transformed by HSV.
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
July 1979,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
April 1975,
International journal of cancer,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
January 1984,
Experimental cell research,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
June 1984,
Virology,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
January 1978,
Virologie,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
December 1993,
Cell structure and function,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
June 1981,
Mutation research,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
March 2002,
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
January 1979,
Virologie,
H Tsuchie, and
T Katsumoto, and
S Hama, and
N Hattori, and
H Morimoto, and
T Kamahora, and
T Kurimura
October 1986,
Cancer letters,
