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Eight patients with cytomegalovirus retinitis in one or both eyes were treated with 9-(1,3 dihydroxy 2-propoxymethyl) guanine. Of the 14 eyes with retinitis, eight demonstrated more than 90% resolution, four had partial improvement, one failed to respond, and one could not be evaluated. Two of the eight patients had chemotherapy-induced immunosuppression and had ocular remissions for at least several months. The remaining six patients had AIDS or probable AIDS and relapsed in five weeks or less after discontinuation of therapy. Dihydroxy propoxymethyl guanine appears to be effective biologically in treating human cytomegalovirus retinitis without the development of unacceptable side effects but a single course of therapy is not capable of eradicating the virus.
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
May 1986,
American journal of ophthalmology,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
April 1986,
American journal of ophthalmology,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
October 1986,
American journal of ophthalmology,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
February 1987,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
June 1987,
American journal of ophthalmology,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
January 1987,
American journal of ophthalmology,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
February 1988,
Transplantation proceedings,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
June 1988,
Transplantation,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
August 1986,
Annals of internal medicine,
A G Palestine, and
G Stevens, and
H C Lane, and
H Masur, and
L S Fujikawa, and
R B Nussenblatt, and
A H Rook, and
J Manischewitz, and
B Baird, and
M Megill
April 1986,
Annals of internal medicine,
