-transparent.png){kind=logo}
We investigated the effect of exogenous mouse alpha- + beta-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4-week-old male ICR mice by intraperitoneal inoculation of MHV-2. Mouse interferon (10(3) IU/mouse/day) was intraperitoneally injected every day. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and development of liver cell necrosis, and prolonged the survival. It was also found that the earlier mouse interferon was administered, the greater was the prolongation of survival.
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
January 1978,
Virology,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
January 1990,
Journal of gastroenterology and hepatology,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
June 1986,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
April 1982,
Virology,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
September 1987,
Antiviral research,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
April 1976,
Virology,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
September 2008,
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
July 1994,
Nihon rinsho. Japanese journal of clinical medicine,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
March 1983,
Cancer research,
Y Kato, and
Y Noda, and
M Unoura, and
N Tanaka, and
K Kobayashi, and
N Hattori, and
K Hatano, and
S Kobayashi
December 1976,
The New England journal of medicine,
