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Specific antibody activities (antibody per weight unit IgG) of serum and CSF against a broad variety of viruses were compared in multiple sclerosis and certain inflammatory diseases of the central nervous system, e.g. neurosyphilis, as well as herpes simplex and zoster encephalitis. No "unspecific" antiviral activities within the CSF compartment were found in the non-MS diseases. The most frequent antibodies locally produced were directed against measles, rubella and zoster antigens. A diagnostic test with these three viruses would give positive results in about 80% of patients with MS. This finding is not as frequent as the oligoclonal pattern of the CSF gamma-globulins but would have a considerably greater diagnostic significance.
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
January 1974,
Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
November 1977,
Annals of neurology,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
April 1973,
Archives of neurology,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
August 1955,
Neurology,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
January 1991,
Critical reviews in clinical laboratory sciences,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
January 1982,
Archivio per le scienze mediche,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
July 1990,
Fortschritte der Neurologie-Psychiatrie,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
September 2020,
Clinics in laboratory medicine,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
December 1982,
Journal of the neurological sciences,
K Felgenhauer, and
H J Schädlich, and
M Nekic, and
R Ackermann
April 1974,
Zeitschrift fur Neurologie,
