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Anti-polysaccharide and anti-diphtheria protective antibodies after 13-valent pneumococcal conjugate vaccination in rheumatoid arthritis patients under immunosuppressive therapy. 2018
Sara Caporuscio, and
Roberto Ieraci, and
Guido Valesini, and
Raffaela Teloni, and
Sabrina Mariotti, and
Francesca Romana Spinelli, and
Claudia Ferlito, and
Simonetta Salemi, and
Andrea Picchianti Diamanti, and
Giorgia Meneguzzi, and
Milica Markovic, and
Mayla Sgrulletti, and
Christina von Hunolstein, and
Luisa Ralli, and
Antonietta Pinto, and
Gerardo Salerno, and
Marco Canzoni, and
Maria Laura Sorgi, and
Bruno Laganà, and
Roberta Di Rosa, and
Roberto Nisini, and
Raffaele D'Amelio
Sapienza Università di Roma, Azienda Ospedaliera Universitaria Sant'Andrea, Roma, Italy.
Immunogenicity of 13-valent pneumococcal polysaccharide (PnPS) conjugate vaccine (PCV13) was evaluated in 38 rheumatoid arthritis patients under immunosuppressive treatment and 20 healthy controls (HC). Antibodies to all PnPS and diphtheria-toxin analogue conjugate protein were measured pre- (T0), 1 (T1), 6 (T2), 12 (T3) months post-immunization. Patients and HC had similar response to individual PnPS. Mean antibody levels to all PnPS but one doubled at T1 compared with T0, with T3 persistence for only 8-7/13 PnPS. Baseline antibody levels was inversely associated with the rate of responders at T1 (T1/T0≥2) to 11/13 PnPS. Few subjects reached protective IgG levels against some serotypes frequently isolated in Italian patients with invasive pneumococcal disease. Antibody response was not influenced by therapy, except the one to PS7F, which was reduced by tumor necrosis factor-α-inhibitors. Vaccination increased also anti-diphtheria IgG. Despite this study substantially confirmed the PCV13 immunogenicity in immunocompromised patients, it also revealed some limitations.
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