Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice. 2018

Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
Department of Anesthesiology, PLA No. 174 Hospital, Chenggong Hospital Affiliated to Xiamen University, Xiamen, Fujian 361003, China.

Hyperbaric oxygen (HBO) preconditioning (PC) has been suggested as a feasible method to provide neuroprotection from postoperative cognitive dysfunction (POCD). However, whether HBO-PC can ameliorate cognitive deficits induced by isoflurane, and the possible mechanism by which it may exert its effect, has not yet been clarified. In the present study, middle-aged mice were exposed to isoflurane anesthesia (1.5 minimal alveolar concentration [MAC]) for 2 h to establish a POCD model. After HBO preconditioning, cognitive function and expression of hippocampal sirtuin 1 (Sirt1), nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were evaluated 24 h following isoflurane treatment, in the presence or absence of Sirt1 knockdown by short hairpin RNA (shRNA). HBO preconditioning increased the expression of Sirt1, Nrf2, and HO-1 and ameliorated memory dysfunction. Meanwhile, Sirt1 knockdown inhibited the expression of Nrf2 and HO-1 and attenuated the HBO preconditioning-associated memory improvement. Our results suggest that the application of HBO preconditioning is a useful treatment for POCD, and that Sirt1 may be a potential molecular target for POCD therapy.

UI MeSH Term Description Entries
D007530 Isoflurane A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297 Male Males
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D008569 Memory Disorders Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. Memory Loss,Age-Related Memory Disorders,Memory Deficits,Memory Disorder, Semantic,Memory Disorder, Spatial,Memory Disorders, Age-Related,Retention Disorders, Cognitive,Semantic Memory Disorder,Spatial Memory Disorder,Age Related Memory Disorders,Age-Related Memory Disorder,Cognitive Retention Disorder,Cognitive Retention Disorders,Deficit, Memory,Deficits, Memory,Memory Deficit,Memory Disorder,Memory Disorder, Age-Related,Memory Disorders, Age Related,Memory Disorders, Semantic,Memory Disorders, Spatial,Memory Losses,Retention Disorder, Cognitive,Semantic Memory Disorders,Spatial Memory Disorders
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006931 Hyperbaric Oxygenation The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke. Oxygenation, Hyperbaric,Hyperbaric Oxygen Therapy,Hyperbaric Oxygen Therapies,Hyperbaric Oxygenations,Oxygen Therapies, Hyperbaric,Oxygen Therapy, Hyperbaric,Oxygenations, Hyperbaric,Therapies, Hyperbaric Oxygen,Therapy, Hyperbaric Oxygen
D000066829 Neuroprotection The physiological processes and techniques used by the body to prevent neuronal injury and degeneration in the central nervous system following acute disorders or as a result of chronic neurodegenerative diseases. Neural Protection,Neuron Protection,Neuronal Protection,Protection, Neural,Protection, Neuron,Protection, Neuronal

Related Publications

Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
November 2017, Neurobiology of learning and memory,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
December 2017, Physiological research,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
March 2013, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
June 2014, Neuroreport,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
August 2015, Molecular neurobiology,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
June 2022, BMC neuroscience,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
December 2020, Experimental neurology,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
September 2013, Brain research bulletin,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
January 2017, Neuroscience letters,
Hu Hong-Qiang, and Shu Mang-Qiao, and Xue Fen, and Liu Shan-Shan, and Cao Hui-Juan, and Hou Wu-Gang, and Yan Wen-Jun, and Peng Zheng-Wu
March 2021, Experimental and therapeutic medicine,
Copied contents to your clipboard!