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The effect of nakom, containing the dopamine precursor levodopa, on the activity of the hypothalamo-hypophysial-adrenal system (HHAS), the content of dopamine in the hypothalamus and the cerebral hemisphere cortex and cAMP in tissues, was studied in experiments on rats. It was revealed, that the preparation in the 2 mg per 100 g dose has a marked inhibiting action on the activity of the HHAS, that is expressed in 2 h by the drop of the level of ACTH, corticosterone, aldosterone in blood that is maintained for 10 hours and disappears 24 hours after the administration. One of the possible mechanisms of the inhibiting action of the preparation on HHAS activity is the increase of dopamine content in the hypothalamus and cerebral hemisphere cortex. The inhibiting action of the preparation on HHAS activity is dose-dependent. The inhibiting influence of nakom on the HHAS activity is realized through the adenylate cyclase system.
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1973,
Problemy endokrinologii,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1976,
Uspekhi fiziologicheskikh nauk,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1973,
Problemy endokrinologii,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1979,
Arkhiv patologii,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1975,
Problemy endokrinologii,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1973,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1977,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
November 1971,
Voprosy okhrany materinstva i detstva,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
September 1976,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
V N Slavnov, and
G V Valueva, and
M I Iatsyk
January 1969,
Eksperimental'naia khirurgiia i anesteziologiia,
