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Unfractionated mononuclear peripheral blood leukocytes (PBL) and nylon wool-nonadherent (B-cell-depleted and T- and null-cell enriched) cells from normal control individuals and untreated patients with chronic lymphocytic leukemia (CLL) were tested for killer cell function in an antibody-dependent cell-mediated cytotoxicity assay. Killer cell activity was present in unfractionated cells from normal individuals and was enriched after removal of adherent cells. Target cell killing by unfractionated mononuclear cells from CLL patients was deficient in 5 of 6 patients tested, but after removal of adherent cells it was approximately equal to that of normal nonadherent cells. Our results indicate that the apparent deficit of killer cells in unfractionated PBL from some CLL patients is due to dilution of killer cells and not to an intrinsic defect in the function of these cells, the presence of suppressor cells in the adherent population, or suppression of killer cell function by serum factors.
J B Smith, and
R P Knowlton, and
L S Koons
November 1983,
Journal of clinical & laboratory immunology,
J B Smith, and
R P Knowlton, and
L S Koons
April 1987,
The Journal of laboratory and clinical medicine,
J B Smith, and
R P Knowlton, and
L S Koons
January 1988,
Nouvelle revue francaise d'hematologie,
J B Smith, and
R P Knowlton, and
L S Koons
October 1982,
Klinische Wochenschrift,
J B Smith, and
R P Knowlton, and
L S Koons
March 1981,
International journal of cancer,
J B Smith, and
R P Knowlton, and
L S Koons
January 1996,
Cancer chemotherapy and pharmacology,
J B Smith, and
R P Knowlton, and
L S Koons
September 1983,
Blood,
J B Smith, and
R P Knowlton, and
L S Koons
September 2008,
Medicina clinica,
J B Smith, and
R P Knowlton, and
L S Koons
January 2014,
mAbs,
J B Smith, and
R P Knowlton, and
L S Koons
January 1980,
Journal of endocrinological investigation,
