-transparent.png){kind=logo}
Methotrexat (250-1100 mg/m2) was administered to 38 patients with malignant tumors by infusion of either 6 hours or of 75 minutes duration. MTX-infusion and continued at 3-6 hours interval for Citrovorum factor rescue was started 2 hours after 24 to 72 hours. 7 different MTX doses and rescue schedules were tested. It could be shown that MTX in the dose range used is effective in various tumors when CF-rescue is not higher than 7% of the administered MTX-dose, only occasionally therapeutic success was observed with higher doses. In the group of patients where CF-rescue was lower than 7% of the MTX dose on 9/14 patients objective tumor-regressions could be achieved. Conclusions drawn are discussed and the necessity of further investigations is emphasized.
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
October 1983,
Nihon Gan Chiryo Gakkai shi,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
July 1977,
Cancer treatment reports,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
January 1980,
Therapeutic drug monitoring,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
April 1980,
Onkologie,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
December 1977,
Cancer treatment reports,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
January 1985,
Cancer drug delivery,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
September 1978,
Cancer treatment reports,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
January 1979,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
December 1977,
Cancer,
G Baumgartner, and
R Heinz, and
K Karrer, and
N Pridun, and
D Lutz
September 1980,
Harefuah,
