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Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen. 2018

Xianwei Li, and Tianzhang Wang, and Yu-Jing Lu, and Shaomin Ji, and Yanping Huo, and Bifu Liu
School of Chemical Engineering and Light Industry, Guangdong University of Technology, No. 100 Waihuan Xi Road Guangzhou Higher Education Mega Center, Guangzhou, 510006, China. xwli@gdut.edu.cn luyj@gdut.edu.cn.

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is described. This reaction features a cheap catalyst, a green oxidant, and readily available starting materials, which make the overall synthesis applicable in the quick access to relevant pharmaceutical molecules with imidazole derived heterocycles.

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