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Chronic granulomatous disease (CGD) is a disorder of phagocytes that is usually inherited as an X chromosome-linked trait. Previous family studies suggested that the CGD locus resides on the distal short arm (Xp22-Xpter). Using cloned, polymorphic DNA probes we have performed a linkage analysis within CGD families that suggests a more proximal location (Xp21). In addition, the CGD locus is proximal to the Duchenne muscular dystrophy locus and lies within a broad region of Xp in which recombination appears to be greater than anticipated on the basis of physical distance between markers. Regional localization of the X chromosome CGD locus should facilitate molecular cloning of the CGD gene and molecular dissection of the phagocyte oxidase system.
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L M Kunkel, and
A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
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R L Baehner, and
L M Kunkel, and
A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
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R L Baehner, and
L M Kunkel, and
A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
February 2024,
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R L Baehner, and
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C Palmer, and
N Heerema, and
S H Orkin
March 1988,
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R L Baehner, and
L M Kunkel, and
A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
December 1990,
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R L Baehner, and
L M Kunkel, and
A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
January 1997,
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R L Baehner, and
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A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
January 1988,
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R L Baehner, and
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A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
February 2005,
Human genetics,
R L Baehner, and
L M Kunkel, and
A P Monaco, and
J L Haines, and
P M Conneally, and
C Palmer, and
N Heerema, and
S H Orkin
January 2018,
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R L Baehner, and
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A P Monaco, and
J L Haines, and
P M Conneally, and
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N Heerema, and
S H Orkin
May 2000,
Haematologica,
