Biomaterial Database

Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells. 2018

Michel Aurrand-Lions, and Stéphane J C Mancini

Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, 13009 Marseille, France. michel.aurrand-lions@inserm.fr.

After birth, the development of hematopoietic cells occurs in the bone marrow. Hematopoietic differentiation is finely tuned by cell-intrinsic mechanisms and lineage-specific transcription factors. However, it is now clear that the bone marrow microenvironment plays an essential role in the maintenance of hematopoietic stem cells (HSC) and their differentiation into more mature lineages. Mesenchymal and endothelial cells contribute to a protective microenvironment called hematopoietic niches that secrete specific factors and establish a direct contact with developing hematopoietic cells. A number of recent studies have addressed in mouse models the specific molecular events that are involved in the cellular crosstalk between hematopoietic subsets and their niches. This has led to the concept that hematopoietic differentiation and commitment towards a given hematopoietic pathway is a dynamic process controlled at least partially by the bone marrow microenvironment. In this review, we discuss the evolving view of murine hematopoietic⁻stromal cell crosstalk that is involved in HSC maintenance and commitment towards B cell differentiation.

UI	MeSH Term	Description	Entries
D001853	Bone Marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.	Marrow,Red Marrow,Yellow Marrow,Marrow, Bone,Marrow, Red,Marrow, Yellow
D002454	Cell Differentiation	Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.	Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014157	Transcription Factors	Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.	Transcription Factor,Factor, Transcription,Factors, Transcription
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D054448	Precursor Cells, B-Lymphoid	Lymphocyte progenitor cells that are restricted in their differentiation potential to the B lymphocyte lineage. The pro-B cell stage of B lymphocyte development precedes the pre-B cell stage.	B-Lymphoid Precursor Cell,Immature B Cell,Immature B-Cell,Immature B-Lymphocyte,Immature B-Lymphocytes,Pre-B Cell,Pre-B Lymphocyte,Pre-B Lymphocytes,Pre-B-Cell,Precursor B-Cell,Precursor B-Lymphocyte,Precursor B-Lymphocytes,Pro-B Cell,Pro-B Lymphocyte,Pro-B-Cell,Progenitor B-Cell,Progenitor B-Lymphocyte,Progenitor B-Lymphocytes,Transitional B-Cell,Transitional B-Lymphocyte,Transitional B-Lymphocytes,B-Lymphoid Precursor Cells,Immature B-Cells,Pre-B Cells,Pre-B-Cells,Precursor B-Cells,Pro-B Cells,Pro-B Lymphocytes,Pro-B-Cells,Progenitor B-Cells,Transitional B-Cells,B Cell, Immature,B Cells, Immature,B Lymphoid Precursor Cell,B Lymphoid Precursor Cells,B-Cell, Immature,B-Cell, Precursor,B-Cell, Progenitor,B-Cell, Transitional,B-Cells, Immature,B-Cells, Precursor,B-Cells, Progenitor,B-Cells, Transitional,B-Lymphocyte, Immature,B-Lymphocyte, Precursor,B-Lymphocyte, Progenitor,B-Lymphocyte, Transitional,B-Lymphocytes, Immature,B-Lymphocytes, Precursor,B-Lymphocytes, Progenitor,B-Lymphocytes, Transitional,Cell, B-Lymphoid Precursor,Cell, Immature B,Cell, Pre-B,Cell, Pro-B,Cells, B-Lymphoid Precursor,Cells, Immature B,Cells, Pre-B,Cells, Pro-B,Immature B Cells,Immature B Lymphocyte,Immature B Lymphocytes,Lymphocyte, Pre-B,Lymphocyte, Pro-B,Lymphocytes, Pre-B,Lymphocytes, Pro-B,Pre B Cell,Pre B Cells,Pre B Lymphocyte,Pre B Lymphocytes,Precursor B Cell,Precursor B Cells,Precursor B Lymphocyte,Precursor B Lymphocytes,Precursor Cell, B-Lymphoid,Precursor Cells, B Lymphoid,Pro B Cell,Pro B Cells,Pro B Lymphocyte,Pro B Lymphocytes,Progenitor B Cell,Progenitor B Cells,Progenitor B Lymphocyte,Progenitor B Lymphocytes,Transitional B Cell,Transitional B Cells,Transitional B Lymphocyte,Transitional B Lymphocytes
D055153	Stem Cell Niche	A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.	Stem Cell Microenvironment,Cell Microenvironment, Stem,Cell Microenvironments, Stem,Cell Niche, Stem,Cell Niches, Stem,Microenvironment, Stem Cell,Microenvironments, Stem Cell,Niche, Stem Cell,Niches, Stem Cell,Stem Cell Microenvironments,Stem Cell Niches
D059630	Mesenchymal Stem Cells	Mesenchymal stem cells, also referred to as multipotent stromal cells or mesenchymal stromal cells are multipotent, non-hematopoietic adult stem cells that are present in multiple tissues, including BONE MARROW; ADIPOSE TISSUE; and WHARTON JELLY. Mesenchymal stem cells can differentiate into mesodermal lineages, such as adipocytic, osteocytic and chondrocytic.	Adipose Tissue-Derived Mesenchymal Stem Cell,Adipose Tissue-Derived Mesenchymal Stromal Cell,Adipose-Derived Mesenchymal Stem Cell,Bone Marrow Mesenchymal Stem Cell,Mesenchymal Stromal Cell,Mesenchymal Stromal Cells,Multipotent Bone Marrow Stromal Cell,Multipotent Mesenchymal Stromal Cell,Adipose Tissue-Derived Mesenchymal Stem Cells,Adipose Tissue-Derived Mesenchymal Stromal Cells,Adipose-Derived Mesenchymal Stem Cells,Adipose-Derived Mesenchymal Stromal Cells,Bone Marrow Mesenchymal Stem Cells,Bone Marrow Stromal Cell,Bone Marrow Stromal Cells,Bone Marrow Stromal Cells, Multipotent,Bone Marrow Stromal Stem Cells,Mesenchymal Progenitor Cell,Mesenchymal Progenitor Cells,Mesenchymal Stem Cell,Mesenchymal Stem Cells, Adipose-Derived,Mesenchymal Stromal Cells, Multipotent,Multipotent Bone Marrow Stromal Cells,Multipotent Mesenchymal Stromal Cells,Stem Cells, Mesenchymal,Wharton Jelly Cells,Wharton's Jelly Cells,Adipose Derived Mesenchymal Stem Cell,Adipose Derived Mesenchymal Stem Cells,Adipose Derived Mesenchymal Stromal Cells,Adipose Tissue Derived Mesenchymal Stem Cell,Adipose Tissue Derived Mesenchymal Stem Cells,Adipose Tissue Derived Mesenchymal Stromal Cell,Adipose Tissue Derived Mesenchymal Stromal Cells,Mesenchymal Stem Cells, Adipose Derived,Progenitor Cell, Mesenchymal,Progenitor Cells, Mesenchymal,Stem Cell, Mesenchymal,Stromal Cell, Mesenchymal,Stromal Cells, Mesenchymal,Wharton's Jelly Cell,Whartons Jelly Cells
D038041	Lymphopoiesis	Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.