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Exposure to inescapable, intermittent footshock elicits an opioid-mediated stress-induced analgesia in rats. We have previously shown that this response is markedly potentiated in adult rats, prenatally exposed to ethanol. To further investigate our hypothesis that endogenous opioid pain-inhibitory systems are modified by prenatal ethanol exposure, we have measured the analgesic response to morphine, in vitro brain opiate receptor binding characteristics, and occupation of brain opiate receptors following systemic administration of morphine. Compared to controls, rats prenatally exposed to ethanol had significantly enhanced morphine analgesia. This enhancement, however, does not appear attributable to changes in number or affinity of mu or delta opiate receptors, or to altered occupation of receptors by morphine.
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
December 1982,
Pharmacology, biochemistry, and behavior,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
October 1991,
Teratology,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
January 2006,
Neurotoxicology and teratology,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
January 1983,
Neurobehavioral toxicology and teratology,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
May 1999,
Alcoholism, clinical and experimental research,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
January 1991,
Neurotoxicology and teratology,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
January 1998,
Pharmacology, biochemistry, and behavior,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
July 2001,
Acta neuropathologica,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
January 1995,
Anatomy and embryology,
L R Nelson, and
A N Taylor, and
J W Lewis, and
B J Branch, and
J C Liebeskind
March 1987,
Behavioral and neural biology,
