-transparent.png){kind=logo}
The effects of alloxan induced diabetes and insulin treatment on rat kidney glomerular ion transport and the oxidative phosphorylation were investigated in order to correlate metabolic and ultrastructural alterations. In alloxan diabetic rats an early decrease of Na+K+ ATPase activity in isolated glomeruli preparations and the subsequent uncoupling of oxidative phosphorylation were observed. These metabolic alterations are associated with structural changes such as the thickening of the basement membrane and the disorganization of both endothelial and mesangial cells. Insulin treatment induces a slow and only partial recovery of metabolic changes. Ultrastructural features of the kidney cortex were almost completely normalized after only two months of insulin treatment.
G Martino, and
L Botte, and
L Gualà, and
C Covello
January 1990,
Pathologica,
G Martino, and
L Botte, and
L Gualà, and
C Covello
December 1968,
Journal d'urologie et de nephrologie,
G Martino, and
L Botte, and
L Gualà, and
C Covello
July 2001,
Journal of submicroscopic cytology and pathology,
G Martino, and
L Botte, and
L Gualà, and
C Covello
January 1984,
International review of experimental pathology,
G Martino, and
L Botte, and
L Gualà, and
C Covello
January 1998,
Hormone research,
G Martino, and
L Botte, and
L Gualà, and
C Covello
July 1965,
Aerospace medicine,
G Martino, and
L Botte, and
L Gualà, and
C Covello
January 1968,
Minerva nefrologica,
G Martino, and
L Botte, and
L Gualà, and
C Covello
March 1989,
Der Internist,
G Martino, and
L Botte, and
L Gualà, and
C Covello
November 1991,
La Revue du praticien,
G Martino, and
L Botte, and
L Gualà, and
C Covello
December 1965,
Investigative ophthalmology,
