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The metabolism of phenazine methosulfate (PMS) by isolated rat hepatocytes is associated with superoxide anion production, and with a substantial decrease in intracellular levels of reduced glutathione, most of which is oxidized to GSSG. A marked loss of protein-free sulfhydryl groups also occurs when intracellular glutathione is depleted, and cytotoxicity follows. These effects are associated with the inhibition of the plasma membrane Ca2+-ATPase and with intracellular accumulation of calcium ion which is preferentially sequestered in mitochondria. Maintenance of protein sulfhydryl groups in the reduced state by dithiothreitol (DTT) prevents the alterations in intracellular calcium homeostasis and protects against toxicity.
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
December 1984,
Archives of biochemistry and biophysics,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
December 1984,
Archives of biochemistry and biophysics,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
January 1972,
Biochemical and biophysical research communications,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
January 1993,
Archives of toxicology,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
September 1982,
Science (New York, N.Y.),
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
February 1984,
Biochemical Society transactions,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
October 1984,
European journal of biochemistry,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
March 1984,
Molecular and biochemical parasitology,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
September 1976,
The American journal of physiology,
I Maridonneau-Parini, and
F Mirabelli, and
P Richelmi, and
G Bellomo
January 1984,
Archives of biochemistry and biophysics,
