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Effect of synthetic rat atrial natriuretic peptide (1-28) (ANP) on the cGMP content was studied using defined nephron segments of rat kidney. ANP elevates cGMP contents in glomeruli in a concentration and time-dependent manner. The increase of cGMP was observed in glomeruli, distal convoluted tubule (DCT) and cortical collecting tubule (CCT) (delta %; 279 +/- 35, 148 +/- 10 and 152 +/- 18, respectively), and no effect was observed in proximal convoluted (PCT) and straight tubule (PST). These results suggest that ANP may act directly on the tubular cells as well as glomeruli. In glomeruli, effects of ANP and carbamylcholine on cGMP contents were additive suggesting that these two agents may act on different receptors. Angiotensin II and norepinephrine failed to affect the ANP-induced cGMP production in the glomeruli.
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
April 1987,
Pflugers Archiv : European journal of physiology,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
April 1987,
Pflugers Archiv : European journal of physiology,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
January 1989,
Peptides,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
January 1990,
Molecular and cellular endocrinology,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
December 1985,
The Journal of clinical investigation,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
April 1990,
Biochemical and biophysical research communications,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
January 1991,
Contributions to nephrology,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
March 1996,
Nippon Ganka Gakkai zasshi,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
January 1980,
The International journal of biochemistry,
S Takeda, and
E Kusano, and
N Murayama, and
Y Asano, and
S Hosoda, and
H Sokabe, and
H Kawashima
January 1999,
Experimental nephrology,
