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OBJECTIVE To study an effect of the protein-peptide preparation cellex on the cerebral tissue processes in case of parenchymal hemorrhage breed under experimental conditions. METHODS The research involved the morphological examination of fragments of cerebral tissues of 57 rabbits of Chinchilla breed in artificially-provoked hemorrhagic stroke. Animals were divided into 2 groups: the first group received cellex once a day during 10 days, the second group received physiological solution in the same doses. The cerebral tissue was examined macroscopically and with histological, immunocytochemical and morphometric methods with subsequent data analysis. CONCLUSIONS A much more pronounced regression of the neurological deficit was observed in the group of animals which were administered cellex. There was a significant increase in volume of active movements in the limbs. No connective tissue changes were observed macroscopically in rabbits of the first group. Besides, the area of destruction decreased in size in comparison with initially diagnosed one. A decline in the rate of the formation of connective tissue was observed in damaged parts of the brain. The microscopic study of the first group showed that the degree of inflammatory and hemodynamic disturbances was much lower and necrosis foci were not detected, however small foci of neoangiogenesis were found.
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
September 1982,
Gaceta medica de Mexico,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
January 1957,
Farmakologiia i toksikologiia,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
May 1980,
Khirurgiia,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
January 1961,
Vestnik Akademii meditsinskikh nauk SSSR,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
June 1967,
Vrachebnoe delo,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
January 1962,
Biulleten' eksperimental'noi biologii i meditsiny,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
November 1966,
Japanese heart journal,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
January 1965,
Transactions of the American Neurological Association,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
September 2021,
The International journal of neuroscience,
L L Korsunskaya, and
S V Vlasenko, and
A A Davydova, and
N V Larina, and
T F Golubova, and
L R Muratova
May 1974,
Current therapeutic research, clinical and experimental,
