-transparent.png){kind=logo}
The mechanism of the formation of the complexes between various nitrosobenzenes and cytochrome P-450 has been investigated. We have observed the formation of these complexes by a new and, as yet, undescribed route. Nitrosobenzene (NOB) itself reacts with cytochrome P-450 in the iron(III) state, in the absence of any exogenous reducing agent, to produce the iron(II)-NOB complex. Apparently, NOB is a ligand that is capable of causing the spontaneous autoreduction of the iron. The reduction of the iron may occur via ligand-induced oxidation of the axially bound thiolate of cytochrome P-450.
Related Publications
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
May 1978,
European journal of biochemistry,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
January 1978,
Methods in enzymology,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
November 1986,
Science (New York, N.Y.),
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
July 1975,
FEBS letters,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
January 1988,
Biomedica biochimica acta,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
July 1984,
Journal of biochemistry,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
July 1971,
Archives of biochemistry and biophysics,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
January 1989,
Drug metabolism reviews,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
June 1975,
FEBS letters,
J M Fukuto, and
J F Brady, and
J N Burstyn, and
R B VanAtta, and
J S Valentine, and
A K Cho
January 1976,
Acta pharmaceutica Suecica,
