BIOMAT Database Logo BIOMAT Database Logo

Prevention and Treatment of Cytomegalovirus Infections in Solid Organ Transplant Recipients. 2018

Christine E Koval
Department of Infectious Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Box G21, Cleveland, OH 44195, USA. Electronic address: kovalc@ccf.org.

Despite advances in prevention and treatment, cytomegalovirus (CMV) infection and disease remain an expected problem in solid organ transplant recipients. Because of the effect of immunosuppressing medications, CMV primary, secondary, and reactivated infection requires antiviral medications to prevent serious direct and indirect effects of the virus. Side effects and drug resistance, however, often limit the capacity of traditional antiviral therapies. This article updates the clinician on current and promising approaches to the management and control of CMV in the solid organ transplant recipient.

UI MeSH Term Description Entries
D003586 Cytomegalovirus Infections Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults. CMV Inclusion,CMV Inclusions,Congenital CMV Infection,Congenital Cytomegalovirus Infection,Cytomegalic Inclusion Disease,Cytomegalovirus Colitis,Cytomegalovirus Inclusion,Cytomegalovirus Inclusion Disease,Cytomegalovirus Inclusions,Inclusion Disease,Perinatal CMV Infection,Perinatal Cytomegalovirus Infection,Renal Tubular Cytomegalovirus Inclusion,Renal Tubular Cytomegalovirus Inclusions,Salivary Gland Virus Disease,Severe Cytomegalovirus Infection,Severe Cytomegalovirus Infections,Infections, Cytomegalovirus,CMV Infection, Congenital,CMV Infection, Perinatal,Colitis, Cytomegalovirus,Congenital CMV Infections,Congenital Cytomegalovirus Infections,Cytomegalic Inclusion Diseases,Cytomegalovirus Colitides,Cytomegalovirus Inclusion Diseases,Cytomegalovirus Infection,Cytomegalovirus Infection, Congenital,Cytomegalovirus Infection, Perinatal,Cytomegalovirus Infection, Severe,Cytomegalovirus Infections, Severe,Disease, Cytomegalic Inclusion,Disease, Cytomegalovirus Inclusion,Diseases, Cytomegalovirus Inclusion,Inclusion Disease, Cytomegalic,Inclusion Disease, Cytomegalovirus,Inclusion Diseases,Inclusion Diseases, Cytomegalovirus,Inclusion, CMV,Inclusion, Cytomegalovirus,Infection, Congenital CMV,Infection, Congenital Cytomegalovirus,Infection, Cytomegalovirus,Infection, Perinatal CMV,Infection, Perinatal Cytomegalovirus,Infection, Severe Cytomegalovirus,Perinatal CMV Infections,Perinatal Cytomegalovirus Infections
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral
D016377 Organ Transplantation Transference of an organ between individuals of the same species or between individuals of different species. Grafting, Organ,Transplantation, Organ,Graftings, Organ,Organ Grafting,Organ Graftings,Organ Transplantations,Transplantations, Organ
D066027 Transplant Recipients Individuals receiving tissues or organs transferred from another individual of the same or different species, or from within the same individual. Recipient, Transplant,Recipients, Transplant,Transplant Recipient

Related Publications

Christine E Koval
Prevention and treatment of cytomegalovirus infections in solid organ transplant recipients.
May 2002, The Pediatric infectious disease journal,
Christine E Koval
Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients.
August 2004, Current opinion in infectious diseases,
Christine E Koval
[Prevention and treatment of fungal infections in solid-organ transplant recipients].
October 1995, Revista clinica espanola,
Christine E Koval
Prevention of infections in solid organ transplant recipients.
March 1999, Transplant infectious disease : an official journal of the Transplantation Society,
Christine E Koval
Cytomegalovirus in solid organ transplant recipients.
December 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Christine E Koval
Ganciclovir therapy of severe cytomegalovirus infections in solid-organ transplant recipients.
July 1988, Transplantation,
Christine E Koval
Prevention and treatment of cytomegalovirus infection in organ transplant recipients.
September 1999, Transplant infectious disease : an official journal of the Transplantation Society,
Christine E Koval
Cytomegalovirus prophylaxis in solid organ transplant recipients.
May 1996, Transplantation,
Christine E Koval
Cytomegalovirus infection in solid organ transplant recipients.
September 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Christine E Koval
Infections in solid-organ transplant recipients.
January 1997, Clinical microbiology reviews,
Copied contents to your clipboard!