Prevention and Treatment of Clostridium difficile-Associated Diarrhea in Solid Organ Transplant Recipients. 2018

Stephanie M Pouch, and Rachel J Friedman-Moraco
Division of Infectious Diseases, Emory University School of Medicine, 101 Woodruff Circle, WMB #2101, Atlanta, GA 30322, USA. Electronic address: spouch@emory.edu.

Clostridium difficile infection is a significant cause of morbidity and mortality in solid organ transplant recipients. Risk factors in this population include frequent hospitalizations, receipt of immunosuppressive agents, and intestinal dysbiosis triggered by several factors, including exposure to broad-spectrum antimicrobials. The incidence and potential for significant adverse outcomes among solid organ transplant recipients with C difficile infection highlight the evolving need for strategic C difficile infection risk factor modification and novel approaches to disease management in this patient population. This review focuses on current concepts related to the prevention and treatment of C difficile infection in solid organ transplant recipients.

UI MeSH Term Description Entries
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D003015 Clostridium Infections Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species. Clostridioides Infections,Clostridioides difficile Infection,Clostridioides perfringens Food Poisoning,Clostridioides perfringens Infections,Clostridioides sordellii Infection,Clostridium difficile Infections,Clostridium sordellii Infections,Clostridium difficile Infection,Clostridium perfringens Food Poisoning,Clostridium perfringens Infections,Clostridium sordellii Infection,Infections, Clostridium,Clostridioides Infection,Clostridioides perfringens Infection,Clostridium Infection,Clostridium perfringens Infection,Infection, Clostridioides difficile,Infection, Clostridioides sordellii,Infection, Clostridium,Infection, Clostridium difficile,Infection, Clostridium sordellii
D003967 Diarrhea An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight. Diarrheas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069467 Fecal Microbiota Transplantation Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient. Fecal Microbiome Transplantation,Fecal Microbiota Transfer,Fecal Microbiota Transplant,Intestinal Microbiome Transfer,Intestinal Microbiome Transplant,Intestinal Microbiome Transplantation,Intestinal Microbiota Transplant,Intestinal Microbiota Transplantation,Donor Feces Infusion,Fecal Transplant,Fecal Transplantation,Intestinal Microbiota Transfer,Donor Feces Infusions,Fecal Microbiome Transplantations,Fecal Microbiota Transfers,Fecal Microbiota Transplantations,Fecal Microbiota Transplants,Fecal Transplantations,Fecal Transplants,Feces Infusion, Donor,Feces Infusions, Donor,Infusion, Donor Feces,Infusions, Donor Feces,Intestinal Microbiome Transfers,Intestinal Microbiome Transplantations,Intestinal Microbiome Transplants,Intestinal Microbiota Transfers,Intestinal Microbiota Transplantations,Intestinal Microbiota Transplants,Microbiome Transfer, Intestinal,Microbiome Transfers, Intestinal,Microbiome Transplant, Intestinal,Microbiome Transplantation, Fecal,Microbiome Transplantation, Intestinal,Microbiome Transplantations, Fecal,Microbiome Transplantations, Intestinal,Microbiome Transplants, Intestinal,Microbiota Transfer, Fecal,Microbiota Transfer, Intestinal,Microbiota Transfers, Fecal,Microbiota Transfers, Intestinal,Microbiota Transplant, Fecal,Microbiota Transplant, Intestinal,Microbiota Transplantation, Fecal,Microbiota Transplantation, Intestinal,Microbiota Transplantations, Fecal,Microbiota Transplantations, Intestinal,Microbiota Transplants, Fecal,Microbiota Transplants, Intestinal,Transfer, Fecal Microbiota,Transfer, Intestinal Microbiome,Transfer, Intestinal Microbiota,Transfers, Fecal Microbiota,Transfers, Intestinal Microbiome,Transfers, Intestinal Microbiota,Transplant, Fecal,Transplant, Fecal Microbiota,Transplant, Intestinal Microbiome,Transplant, Intestinal Microbiota,Transplantation, Fecal,Transplantation, Fecal Microbiome,Transplantation, Fecal Microbiota,Transplantation, Intestinal Microbiome,Transplantation, Intestinal Microbiota,Transplantations, Fecal,Transplantations, Fecal Microbiome,Transplantations, Fecal Microbiota,Transplantations, Intestinal Microbiome,Transplantations, Intestinal Microbiota,Transplants, Fecal,Transplants, Fecal Microbiota,Transplants, Intestinal Microbiome,Transplants, Intestinal Microbiota
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D016377 Organ Transplantation Transference of an organ between individuals of the same species or between individuals of different species. Grafting, Organ,Transplantation, Organ,Graftings, Organ,Organ Grafting,Organ Graftings,Organ Transplantations,Transplantations, Organ

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