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Monitoring and Updating of Action Selection for Goal-Directed Behavior through the Striatal Direct and Indirect Pathways. 2018
Satoshi Nonomura, and
Kayo Nishizawa, and
Yutaka Sakai, and
Yasuo Kawaguchi, and
Shigeki Kato, and
Motokazu Uchigashima, and
Masahiko Watanabe, and
Ko Yamanaka, and
Kazuki Enomoto, and
Satomi Chiken, and
Hiromi Sano, and
Shogo Soma, and
Junichi Yoshida, and
Kazuyuki Samejima, and
Masaaki Ogawa, and
Kazuto Kobayashi, and
Atsushi Nambu, and
Yoshikazu Isomura, and
Minoru Kimura
Brain Science Institute, Tamagawa University, Machida, Tokyo 194-8610, Japan.
The basal ganglia play key roles in adaptive behaviors guided by reward and punishment. However, despite accumulating knowledge, few studies have tested how heterogeneous signals in the basal ganglia are organized and coordinated for goal-directed behavior. In this study, we investigated neuronal signals of the direct and indirect pathways of the basal ganglia as rats performed a lever push/pull task for a probabilistic reward. In the dorsomedial striatum, we found that optogenetically and electrophysiologically identified direct pathway neurons encoded reward outcomes, whereas indirect pathway neurons encoded no-reward outcome and next-action selection. Outcome coding occurred in association with the chosen action. In support of pathway-specific neuronal coding, light activation induced a bias on repeat selection of the same action in the direct pathway, but on switch selection in the indirect pathway. Our data reveal the mechanisms underlying monitoring and updating of action selection for goal-directed behavior through basal ganglia circuits.
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