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Linkage mapping - utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers - is now 100 years old. Schistosome parasites are exquisitely well suited to linkage mapping approaches because genetic crosses can be conducted in the laboratory, thousands of progeny are produced, and elegant experimental work over the last 75 years has revealed heritable genetic variation in multiple biomedically important traits such as drug resistance, host specificity, and virulence. Application of this approach is timely because the improved genome assembly for Schistosoma mansoni and developing molecular toolkit for schistosomes increase our ability to link phenotype with genotype. We describe current progress and potential future directions of linkage mapping in schistosomes.
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
December 2021,
Virulence,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
May 1997,
Genetics,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
May 1964,
Journal of bacteriology,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
December 2022,
Parasitology international,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
May 2016,
Science (New York, N.Y.),
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
January 2011,
Methods in molecular biology (Clifton, N.J.),
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
January 1987,
Journal of psychiatric research,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
June 2009,
The Korean journal of parasitology,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
December 2022,
Parasitology international,
Timothy J C Anderson, and
Philip T LoVerde, and
Winka Le Clec'h, and
Frédéric D Chevalier
September 1980,
Annals of internal medicine,
