BIOMAT Database Logo BIOMAT Database Logo

Synthesis and Antiviral Activity of Water-Soluble Polycarboxylic Derivatives of [60]Fullerene Loaded with 3,4-Dichlorophenyl Units. 2018

Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Institute for Problems of Chemical Physics of RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia.

We have synthesized a series of water-soluble polycarboxylic derivatives of [60]fullerene with a gradually changed polarity by combining three to five polar (ionic) malonate addends with two to zero hydrophobic dichlorobenzene units and explored their antiviral activity. It has been shown that decreasing the number of the ionogenic carboxylic groups in the molecules enhanced their antiviral activity against HIV-1 and suppressed their action against HIV-2. The obtained results implied that the charged states and hydrophobicity of the water-soluble polycarboxylic fullerene derivatives affect significantly their biological properties.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D011108 Polymers Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS). Polymer
D002264 Carboxylic Acids Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic. Carboxylic Acid,Acid, Carboxylic,Acids, Carboxylic
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D002722 Chlorobenzenes Aromatic organic compounds with the chemical formula C6H5Cln.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D015497 HIV-1 The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. Human immunodeficiency virus 1,HIV-I,Human Immunodeficiency Virus Type 1,Immunodeficiency Virus Type 1, Human

Related Publications

Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene.
August 2011, Chemical communications (Cambridge, England),
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Synthesis and anti-HIV properties of new water-soluble bis-functionalized[60]fullerene derivatives.
December 2003, Bioorganic & medicinal chemistry letters,
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Synthesis and characterization of water-soluble amino fullerene derivatives
April 2000, Organic letters,
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity.
September 2020, Chemical communications (Cambridge, England),
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Chlorofullerene C60Cl6: a precursor for straightforward preparation of highly water-soluble polycarboxylic fullerene derivatives active against HIV.
September 2007, Organic & biomolecular chemistry,
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Photocytotoxicity of water-soluble fullerene derivatives.
August 1996, Bioscience, biotechnology, and biochemistry,
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
C(60) and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation.
November 1999, Journal of medicinal chemistry,
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity.
January 2020, Chemical communications (Cambridge, England),
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Hemolytic effects of water-soluble fullerene derivatives.
December 2004, Journal of medicinal chemistry,
Ilya I Voronov, and Vyacheslav M Martynenko, and Alexander V Chernyak, and Jan Balzarini, and Dominique Schols, and Pavel A Troshin
Water-soluble fullerene derivatives for drug discovery.
January 2012, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi,
Copied contents to your clipboard!