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Reduction of aromatic nitriles into aldehydes using calcium hypophosphite and a nickel precursor. 2018

Rim Mouselmani, and Ali Hachem, and Ali Alaaeddine, and Estelle Métay, and Marc Lemaire
Laboratoire de Catalyse, Synthèse et Environnement, Institute de Chimie et Biochimie Moléculaires et Supramoléculaire (ICBMS), CNRS, UMR 5246, Université Claude Bernard Lyon 1, Campus de la Doua, 43 boulevard du 11 Novembre 1918, bâtiment Curien-CPE, 69622 Villeurbanne cedex, France. Estelle.metay@univ-lyon1.fr.

Herein we report the reduction of aromatic nitriles into aldehydes with calcium hypophosphite in the presence of base and nickel(ii) complex in a water/ethanol mixture. This catalytic system reduced efficiently a series of aromatic nitriles bearing different functional groups such as -Cl, -CF3, -Br, -CH3, -OCH3, -COOCH2CH3, -OH and -CHO. The corresponding aldehydes were isolated in moderate to excellent yields (30-94%).

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