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A comprehensive evaluation of the cellular immune system (total T-cell, helper cell, suppressor cell, and natural killer cell numbers; in vitro interleukin-2 production, T-cell responses to mitogens and antigens, serum beta 2 microglobulin levels, and delayed hypersensitivity skin tests) was performed on 36 HTLV-III seronegative and 16 HTLV-III seropositive healthy homosexual men, 48 asymptomatic homosexual men with the chronic lymphadenopathy syndrome, 41 patients with AIDS, and 29 heterosexual controls without any known risk factors for AIDS. Our studies demonstrate that HTLV-III seronegative homosexual men have normal cellular immunity and are comparable to heterosexual controls. The abnormalities of lymphocyte subsets observed in HTLV-III seropositive healthy homosexual men are comparable to subjects with chronic lymphadenopathy. Assays of lymphocyte function, with the exception of delayed type hypersensitivity (DTH) skin tests, are similar in each group except patients with AIDS. Subjects with chronic lymphadenopathy were less responsive to DTH skin tests and HTLV-III seropositive healthy homosexuals were comparable to chronic lymphadenopathy subjects. We conclude that immunologic abnormalities in homosexual men are attributable to infection with HTLV-III.
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
March 1985,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
April 1985,
Clinical and experimental immunology,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
January 1986,
Clinical and investigative medicine. Medecine clinique et experimentale,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
January 1987,
Sexually transmitted diseases,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
September 1985,
The Medical journal of Australia,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
July 1985,
Klinische Wochenschrift,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
September 1985,
Cancer research,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
March 1986,
The Medical journal of Australia,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
January 1987,
Archives of dermatological research,
B S Dobozin, and
F N Judson, and
D L Cohn, and
K A Penley, and
P E Rickmann, and
M J Blaser, and
P S Sarin, and
S H Weiss, and
C H Kirkpatrick
June 1985,
The New England journal of medicine,
