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Dolichols are isoprenologues that are found in almost all tissues and whose biochemical function, aside from dolichol phosphate precursors, is not known. In addition, an understanding of the organizational and dynamic properties of dolichols in biological membranes has not been forthcoming. The purpose of the experiments reported here were to examine the effects of dolichol on the physical properties of mouse synaptic plasma membranes (SPM). Differential polarized phase fluorometry indicated that dolichol both fluidized and rigidified SPM. Membrane areas detected by diphenylhexatriene and trans-parinaric acid were selectively fluidized and rigidified, respectively. It also was found that the spin label, 5-doxyl stearic acid indicated that dolichol reduced membrane fluidity. These results report for the first time a structural effect of dolichol on a biological membrane.
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
January 1987,
Peptides,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
March 2020,
Physical review. E,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
October 1989,
Molecular and chemical neuropathology,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
October 1977,
FEBS letters,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
April 1980,
Biophysical journal,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
January 2012,
Biophysical chemistry,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
January 1997,
Methods in molecular biology (Clifton, N.J.),
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
January 1974,
Journal of neurochemistry,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
June 1979,
Biochimica et biophysica acta,
W G Wood, and
C Gorka, and
L S Williamson, and
R Strong, and
A Y Sun, and
G Y Sun, and
F Schroeder
January 1976,
Biochemical Society transactions,
