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We have characterized a mutant of avian myeloblastosis virus (strain GA907/7) that shows a reduced capacity to transform myelomonocytic cells at the nonpermissive temperature. Myeloblasts transformed by this mutant suffer a substantial decrease in the amount of the transforming protein p45v-myb when shifted from the permissive to the nonpermissive temperature. We presume that the 5- to 10-fold decrease in the amount of p45v-myb causes the loss of the transformed phenotype. The decrease is due to a reduction in the level of v-myb mRNA. Mutant GA907/7 thus provides genetic evidence that p45v-myb is the transforming protein of avian myeloblastosis virus and apparently represents an unusual defect in the production or stability of mRNA.
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
March 1983,
Proceedings of the National Academy of Sciences of the United States of America,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
January 1976,
Virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
June 1973,
Virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
February 1990,
Journal of virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
April 1983,
Journal of virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
March 1988,
Journal of virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
August 1976,
Virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
November 1976,
Virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
December 1985,
Journal of virology,
M G Moscovici, and
K H Klempnauer, and
G Symonds, and
J M Bishop, and
C Moscovici
September 1969,
Journal of bacteriology,
