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All four factors which theoretically may affect the renal vein renin ratio in unilateral renal artery stenosis--increased renin secretion and diminished renal plasma flow on the stenotic side; suppressed renin secretion and renin extraction on the contralateral side--have been assessed. In a series of patients with unilateral renal artery stenosis, the renal vein ratio of active renin was more closely related to the reduction of renal plasma flow than to renin secretion rate on the affected side. On the contralateral side renin secretion was suppressed while angiotensin II was extracted. During long-term treatment with the converting enzyme inhibitor enalapril, peripheral plasma angiotensin II was lowered, while active renin concentration was markedly elevated, both in arterial plasma and in renal venous plasma of the stenotic kidney; the contralateral kidney became a net extractor of active renin. Thus, all 4 factors which theoretically affect the renal vein renin ratio can operate clinically. Both before and during enalapril, the affected kidney secreted inactive renin.
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
December 1984,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
September 1972,
Annals of internal medicine,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
January 1978,
Contributions to nephrology,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
January 2015,
Seminars in dialysis,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
January 1987,
Clinical and experimental hypertension. Part A, Theory and practice,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
March 2012,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
June 2005,
Zhonghua xin xue guan bing za zhi,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
August 1970,
Annals of surgery,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
December 1990,
American journal of hypertension,
L S Malatino, and
A M Cumming, and
G P Hodsman, and
B J Leckie, and
A F Lever, and
D M Tillman, and
D J Webb, and
J J Morton, and
J I Robertson
November 1980,
The Journal of urology,
