Biomaterial Database

[IMPAIRMENTS OF GLUTAMATERGIC TRANSMISSION IN THE BASOLATERAL NUCLEUS OF THE AMYGDALA IN THE DEVELOPMENT OF ALCOHOL DEPENDENCE]. 2016

A V Akhmadeev, and L B Kalimullina

In this review for the first time systematized literature data about the impairments of glutamatergic transmission in the basolateral nucleus of the Amygdala which leading to increased levels of anxiety. It is known that increased anxiety is seen as a main motivating factor of desire for alcohol, thus involved in the manifestation of alcohol dependence. Reviewed structural-functional alterations in ionotropic and metabotropic glutamate receptors in acute, chronic ethanol exposure and withdrawal. Presents the data on the role of glutamate transporters in the pathogenesis of alcoholism.

UI	MeSH Term	Description	Entries
D009435	Synaptic Transmission	The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.	Neural Transmission,Neurotransmission,Transmission, Neural,Transmission, Synaptic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000437	Alcoholism	A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)	Alcohol Abuse,Alcoholic Intoxication, Chronic,Ethanol Abuse,Alcohol Addiction,Alcohol Dependence,Alcohol Use Disorder,Abuse, Alcohol,Abuse, Ethanol,Addiction, Alcohol,Alcohol Use Disorders,Chronic Alcoholic Intoxication,Dependence, Alcohol,Intoxication, Chronic Alcoholic,Use Disorders, Alcohol
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017470	Receptors, Glutamate	Cell-surface proteins that bind glutamate and trigger changes which influence the behavior of cells. Glutamate receptors include ionotropic receptors (AMPA, kainate, and N-methyl-D-aspartate receptors), which directly control ion channels, and metabotropic receptors which act through second messenger systems. Glutamate receptors are the most common mediators of fast excitatory synaptic transmission in the central nervous system. They have also been implicated in the mechanisms of memory and of many diseases.	Excitatory Amino Acid Receptors,Glutamate Receptors,Receptors, Excitatory Amino Acid,Excitatory Amino Acid Receptor,Glutamate Receptor,Receptor, Glutamate
D066272	Basolateral Nuclear Complex	A set of amygdalar nuclei bordered laterally by the EXTERNAL CAPSULE and medially by the CENTRAL AMYGDALOID NUCLEUS.	Amygdaloid Basolateral Complex,Basolateral Amygdala,Basolateral Amygdaloid Nucleus,Accessory Basal Amygdaloid Nucleus,Accessory Basal Nucleus,Basal Amygdaloid Nucleus,Basal Nucleus of the Amygdala,Basolateral Nuclear Group,Deep Nuclei, Amygdala,Deep Nuclei, Amygdaloid,Lateral Amygdaloid Nucleus,Lateral Nucleus of Amygdala,Lateral Principal Nucleus of Amygdala,Paralaminar Nucleus,Amygdala Deep Nuclei,Amygdala Deep Nucleus,Amygdala Lateral Nucleus,Amygdala, Basolateral,Amygdaloid Basolateral Complices,Amygdaloid Deep Nuclei,Amygdaloid Deep Nucleus,Amygdaloid Nucleus, Basal,Amygdaloid Nucleus, Basolateral,Amygdaloid Nucleus, Lateral,Basal Nucleus, Accessory,Basolateral Amygdalas,Basolateral Complex, Amygdaloid,Basolateral Nuclear Complices,Basolateral Nuclear Groups,Deep Nucleus, Amygdala,Deep Nucleus, Amygdaloid,Nuclear Complex, Basolateral,Nuclear Complices, Basolateral,Nuclear Group, Basolateral,Nuclear Groups, Basolateral,Nucleus, Accessory Basal,Nucleus, Basolateral Amygdaloid