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Poly(A)+ RNA was isolated from 9 specimens of human primary hepatic carcinoma, 1 non-tumorous liver tissue adjacent to cancer and 1 normal liver tissue samples. The Oligo-dT cellulose-purified poly(A)+ RNAs were subjected to formaldehyde agarose gel electrophoresis, Northern transfer and hybridization with various oncogene probes. Two RNA species, 5.6 kb and 2.2 kb were identified by N-ras gene hybridization in 6 out of 9 mRNA samples from primary hepatic carcinoma specimen. N-ras specific mRNA was not detectable in mRNA samples from normal human liver and tumor surrounding cirrhotic tissue. No detectable hybridization of mRNA from hepatoma and normal liver with Ki-ras or Ha-ras was observed. As human N-ras gene has been identified in DNA of mouse transfectants transformed with PHC DNA, it strongly suggests that N-ras gene might be responsible for the transforming activity of part of cases of human liver cancer.
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
October 1996,
Neurologia medico-chirurgica,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
April 1998,
World journal of gastroenterology,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
August 2000,
Cancer genetics and cytogenetics,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
January 2020,
Breast cancer research and treatment,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
December 1998,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
July 1985,
Nucleic acids research,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
April 2007,
Histology and histopathology,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
September 1983,
Cell,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
December 2007,
Pharmacological research,
L F Hu, and
L P Wang, and
L W Ju, and
L H Huang, and
X L Li, and
X Z Li, and
J R Gu
July 1991,
Molecular and cellular biology,
