BIOMAT Database Logo BIOMAT Database Logo

[Molecular mechanism of Shaofu Zhuyu decoction in treating endometriosis dysmenorrhea based on GPER2/MAPK/STAT1 axis]. 2018

Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Gansu University of Chinese Medicine, Lanzhou 730000， China.

The aim of this paper is to study the molecular mechanism of Shaofu Zhuyu decoction in treating dysmenorrhea of endometriosis based on GPER2/MAPK/STAT1 axis. In this study, HE staining was used to observe the pathological changes of the rats in each group. The levels of TNF-α and IL-6 were detected by ELISA assay. The mRNA expressions of neurotransmitter receptor (NK1) and GPER were detected by qPCR. The protein contents of MAPK and STAT1 were detected by Western blot. According to the results, compared with the model group, Shaofu Zhuyu decoction could significantly improve the inflammation of the ectopic uterine cavity tissue, decrease the contents of TNF-α and IL-6 in the uterine cavity, the mRNA expressions of NK1 and GPER, and the protein expressions of MAPK and STAT1. In conclusion, Shaofu Zhuyu decoction could effectively inhibit the expressions of GPER2, MAPK and STAT1, decrease the levels of TNF-α, IL-6 and NK1 mRNA and relieve the inflammatory pain in patients with endometriosis.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D011960 Receptors, Estrogen Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important. Estrogen Receptor,Estrogen Receptors,Estrogen Nuclear Receptor,Estrogen Receptor Type I,Estrogen Receptor Type II,Estrogen Receptors Type I,Estrogen Receptors Type II,Receptor, Estrogen Nuclear,Receptors, Estrogen, Type I,Receptors, Estrogen, Type II,Nuclear Receptor, Estrogen,Receptor, Estrogen
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D004412 Dysmenorrhea Painful menstruation. Menstruation, Painful,Pain, Menstrual,Dysmenorrheas,Menstrual Pain,Menstrual Pains,Menstruations, Painful,Painful Menstruation,Painful Menstruations,Pains, Menstrual
D004715 Endometriosis A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum. Endometrioma,Endometriomas,Endometrioses
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014409 Tumor Necrosis Factor-alpha Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. Cachectin,TNF-alpha,Tumor Necrosis Factor Ligand Superfamily Member 2,Cachectin-Tumor Necrosis Factor,TNF Superfamily, Member 2,TNFalpha,Tumor Necrosis Factor,Cachectin Tumor Necrosis Factor,Tumor Necrosis Factor alpha
D014599 Uterus The hollow thick-walled muscular organ in the female PELVIS. It consists of the fundus which is the site of EMBRYO IMPLANTATION and FETAL DEVELOPMENT. Beyond the isthmus at the perineal end of fundus, is CERVIX UTERI (the neck) opening into VAGINA. Beyond the isthmi at the upper abdominal end of fundus, are the FALLOPIAN TUBES. Fundus Uteri,Uteri,Uterine Cornua,Uterine Fundus,Uterus Cornua,Womb,Cornua, Uterine,Fundus Uterus,Fundus, Uterine,Uteri, Fundus,Wombs
D015850 Interleukin-6 A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS. Hepatocyte-Stimulating Factor,Hybridoma Growth Factor,IL-6,MGI-2,Myeloid Differentiation-Inducing Protein,Plasmacytoma Growth Factor,B Cell Stimulatory Factor-2,B-Cell Differentiation Factor,B-Cell Differentiation Factor-2,B-Cell Stimulatory Factor 2,B-Cell Stimulatory Factor-2,BSF-2,Differentiation Factor, B-Cell,Differentiation Factor-2, B-Cell,IFN-beta 2,IL6,Interferon beta-2,B Cell Differentiation Factor,B Cell Differentiation Factor 2,B Cell Stimulatory Factor 2,Differentiation Factor 2, B Cell,Differentiation Factor, B Cell,Differentiation-Inducing Protein, Myeloid,Growth Factor, Hybridoma,Growth Factor, Plasmacytoma,Hepatocyte Stimulating Factor,Interferon beta 2,Interleukin 6,Myeloid Differentiation Inducing Protein,beta-2, Interferon

Related Publications

Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
[Mechanism of Shaofu Zhuyu Decoction in treatment of EMT induced dysmenorrhea based on network pharmacology and molecular docking].
December 2021, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
[Mechanism of Shaofu Zhuyu Decoction in treatment of endometriosis-associated dysmenorrhea with syndrome of cold coagulation and blood stasis based on MSK1/2].
September 2022, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Herbal medicine (Shaofu Zhuyu decoction) for treating primary dysmenorrhea: A systematic review of randomized clinical trials.
April 2016, Maturitas,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Herbal medicine Shaofu Zhuyu decoction for primary dysmenorrhea: a systematic review protocol.
January 2016, Systematic reviews,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Shaofu Zhuyu decoction for primary dysmenorrhea: A protocol for systematic review and meta-analysis.
June 2021, Medicine,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
[Shaofu Zhuyu Decoction attenuates fibrosis in endometriosis through regulating PTEN/Akt/mTOR signaling pathway].
June 2023, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Shaofu Zhuyu Decoction Regresses Endometriotic Lesions in a Rat Model.
January 2018, Evidence-based complementary and alternative medicine : eCAM,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Effects and mechanisms of Shaofu-Zhuyu decoction and its major bioactive component for Cold - Stagnation and Blood - Stasis primary dysmenorrhea rats.
June 2016, Journal of ethnopharmacology,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
Inhibitory effects of active fraction and its main components of Shaofu Zhuyu decoction on uterus contraction.
January 2010, The American journal of Chinese medicine,
Yu-Hong Cui, and Jing Wu, and Wei Cai, and Juan Du, and Jun-Min Cao, and Xiu-Jia Ji, and Zi-Han Gong
[Analysis of morphic traits between physical and chemical properties and chemical constituents based on different combinations of Shaofu Zhuyu decoction].
May 2011, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Copied contents to your clipboard!