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Electron-microscopic analysis of iris biopsy material was carried out paying particular attention to vessels and infiltrating cells. Characteristic changes of vessels and cells were found in two cases. One showed abundant lymphodiapedesis, perivascular infiltration, and vessels appearing morphologically normal. The other showed diffuse infiltration of cells and numerous fenestrated newly formed vessels. In the latter, three different types of opening in the endothelium were observed: (1) separation of intercellular junctions; (2) small pores or defects in the endothelium, and (3) large holes or defects in the endothelium. Cell leakage from normal and newly formed vessels was considered. We concluded that lymphocytes may migrate through the cytoplasm within membrane-bounded vesicles in normal vessels, whereas in newly formed fenestrated vessels cells, including small lymphocytes, may pass through three different types of opening in the endothelium.
K Mukuno, and
R Witmer, and
P Gruber
November 1984,
Journal of the American Optometric Association,
K Mukuno, and
R Witmer, and
P Gruber
January 1974,
Acta ophthalmologica,
K Mukuno, and
R Witmer, and
P Gruber
October 1971,
Nihon ganka kiyo,
K Mukuno, and
R Witmer, and
P Gruber
January 1985,
Japanese journal of ophthalmology,
K Mukuno, and
R Witmer, and
P Gruber
April 1985,
Nippon Ganka Gakkai zasshi,
K Mukuno, and
R Witmer, and
P Gruber
May 1973,
Nippon Ganka Gakkai zasshi,
K Mukuno, and
R Witmer, and
P Gruber
January 1991,
Japanese journal of ophthalmology,
K Mukuno, and
R Witmer, and
P Gruber
December 1978,
Acta ophthalmologica,
K Mukuno, and
R Witmer, and
P Gruber
October 1983,
The American journal of surgical pathology,
K Mukuno, and
R Witmer, and
P Gruber
January 1983,
Nippon Ganka Gakkai zasshi,
