Detection of Angiotensin II type I-receptor antibodies in transplant glomerulopathy. 2018

Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
Division of Nephrology and Dialysis, ASO Civico, Chivasso, Italy.

Transplant glomerulopathy (TG) is an important cause of late graft loss. The role of angiotensin type 1-receptor antibodies (AT1 R-Ab) in TG is not known. All the TG cases (N = 137) between January 2007 and December 2014 (N = 1410) were analyzed. Donor-specific anti-HLA antibodies (DSA) at the time of biopsy and AT1 R-Ab IgG (positive, >17 UI/mL; "at risk," 10-17 UI/mL; negative, <10 UI/mL) in pre-transplant sera (PT-Ab) and at biopsy time (BT-Ab) were studied. AT1 R-PT-Ab+ and AT1 R-BT-Ab+ patients were 16.5% (51.5% "at risk") and 11.5% (27.4% "at risk"), respectively. Clinical correlations were found between AT1 R-Ab and HCV infection, number of transplants, and age. Considering Banff scores, ptc was higher in DSA+ patients vs AT1 R-PT-Ab+ (P = 0.002) or AT1 R-BT-Ab+ (P = 0.001) without differences in g and chronicity score (ci + ct); cg showed lower scores in DSA+ patients vs AT1 R-BT-Ab+ (P = 0.001). Graft survival was not influenced by the presence of AT1 R-Ab, AT1-R-Ab titer or MFI, but we observed a longer graft survival in patients with both AT1 R-BT-Ab+ or "at risk" and DSA+ vs patients positive only for DSA (P = 0.02), for AT1 R-BT-Ab (P = 0.019) or AT1 R-BT-Ab "at risk" (P = 0.039). AT1 R-Ab showed no independent prognostic role in TG in this pilot analysis.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006084 Graft Rejection An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. Transplant Rejection,Rejection, Transplant,Transplantation Rejection,Graft Rejections,Rejection, Graft,Rejection, Transplantation,Rejections, Graft,Rejections, Transplant,Rejections, Transplantation,Transplant Rejections,Transplantation Rejections
D006085 Graft Survival The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host. Graft Survivals,Survival, Graft,Survivals, Graft
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
August 2019, Human immunology,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
August 2019, Human immunology,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
December 2022, Pediatric transplantation,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
November 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
January 2013, Methods in molecular biology (Clifton, N.J.),
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
September 2018, Annals of laboratory medicine,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
July 2015, Clinical transplantation,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
October 2023, Transplant immunology,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
October 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Stefania Bussolino, and Caterina Dolla, and Claudia Ariaudo, and Federica Civiletti, and Maria Messina, and Alberto Mella, and Cristiana Caorsi, and Antonio Amoroso, and Antonella Barreca, and Mauro Papotti, and Sara Giunti, and Fabrizio Fop, and Luigi Biancone
July 2011, Hypertension (Dallas, Tex. : 1979),
Copied contents to your clipboard!