BIOMAT Database Logo BIOMAT Database Logo

H-2 gene complementation in cytotoxic T cell responses of female against male cells. 1977

H von Boehmer, and C G Fathman, and W Haas

H-2 gene-dependent nonresponsiveness and responsiveness to H-2-matched male cells can be observed in cytotoxic assays in several mouse strains. H-2 genes of several low responder strains can complement each other in cis or trans position to produce high responders. One of the H-2 gene products functions at the level of antigen-presenting cells (stimulators, targets), the other must be expressed in the responding T cell population.

UI MeSH Term Description Entries
D008297 Male Males
D008805 Mice, Inbred A An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. Mouse, Inbred A,Inbred A Mice,Inbred A Mouse
D008808 Mice, Inbred CBA An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH. Mice, CBA,Mouse, CBA,Mouse, Inbred CBA,CBA Mice,CBA Mice, Inbred,CBA Mouse,CBA Mouse, Inbred,Inbred CBA Mice,Inbred CBA Mouse
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D003601 Cytotoxicity Tests, Immunologic The demonstration of the cytotoxic effect on a target cell of a lymphocyte, a mediator released by a sensitized lymphocyte, an antibody, or complement. AHG-CDC Tests,Anti-Human Globulin Complement-Dependent Cytotoxicity Tests,Microcytotoxicity Tests,Anti Human Globulin Complement Dependent Cytotoxicity Tests,Anti-Human Globulin Complement-Dependent Cytotoxicity Test,Antiglobulin-Augmented Lymphocytotoxicity Test,Antiglobulin-Augmented Lymphocytotoxicity Tests,Cytotoxicity Test, Immunologic,Cytotoxicity Tests, Anti-Human Globulin Complement-Dependent,Cytotoxicity Tests, Immunological,Immunologic Cytotoxicity Test,Immunologic Cytotoxicity Tests,Lymphocytotoxicity Test, Antiglobulin-Augmented,Lymphocytotoxicity Tests, Antiglobulin-Augmented,Microcytotoxicity Test,AHG CDC Tests,AHG-CDC Test,Anti Human Globulin Complement Dependent Cytotoxicity Test,Antiglobulin Augmented Lymphocytotoxicity Test,Antiglobulin Augmented Lymphocytotoxicity Tests,Cytotoxicity Test, Immunological,Cytotoxicity Tests, Anti Human Globulin Complement Dependent,Immunological Cytotoxicity Test,Immunological Cytotoxicity Tests,Lymphocytotoxicity Test, Antiglobulin Augmented,Lymphocytotoxicity Tests, Antiglobulin Augmented
D005260 Female Females
D005796 Genes A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms. Cistron,Gene,Genetic Materials,Cistrons,Genetic Material,Material, Genetic,Materials, Genetic
D005816 Genetic Complementation Test A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell. Allelism Test,Cis Test,Cis-Trans Test,Complementation Test,Trans Test,Allelism Tests,Cis Tests,Cis Trans Test,Cis-Trans Tests,Complementation Test, Genetic,Complementation Tests,Complementation Tests, Genetic,Genetic Complementation Tests,Trans Tests
D006648 Histocompatibility The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts. HLA Incompatibility,Histoincompatibility,Human Leukocyte Antigen Incompatibility,Immunocompatibility,Tissue Compatibility,Compatibility, Tissue,HLA Incompatibilities,Histocompatibilities,Histoincompatibilities,Immunocompatibilities,Incompatibility, HLA,Tissue Compatibilities

Related Publications

H von Boehmer, and C G Fathman, and W Haas
H-2 complementation in anti-H-Y cytotoxic T-cell responses can occur in chimeric mice.
December 1978, Proceedings of the National Academy of Sciences of the United States of America,
H von Boehmer, and C G Fathman, and W Haas
The failure of female cells to present in vitro the male H-Y antigen for secondary cytotoxic T-cell responses.
January 1985, Immunogenetics,
H von Boehmer, and C G Fathman, and W Haas
T-cell hyperreactivity of NZB mice against H-2 identical cells. Equal cytotoxic T lymphocyte precursor frequency against H-2 allogeneic and H-2 syngeneic target cells in NZB.
January 1983, Rheumatology international,
H von Boehmer, and C G Fathman, and W Haas
H-2-linked murine cytotoxic T cell responses specific for sendai virus-infected cells.
December 1978, European journal of immunology,
H von Boehmer, and C G Fathman, and W Haas
Immune-response gene control of cytotoxic T-cell responses to H-Y.
March 1977, Transplantation proceedings,
H von Boehmer, and C G Fathman, and W Haas
Cytotoxic T cells recognize male antigen and H-2 as distinct entities.
April 1978, The Journal of experimental medicine,
H von Boehmer, and C G Fathman, and W Haas
Cytotoxic T cell lysis of H-2-negative murine sarcoma cells.
May 1986, European journal of immunology,
H von Boehmer, and C G Fathman, and W Haas
Cytotoxic T cell responses against mesothelioma by apoptotic cell-pulsed dendritic cells.
June 2004, American journal of respiratory and critical care medicine,
H von Boehmer, and C G Fathman, and W Haas
Alloreactive cytotoxic T lymphocyte responses to H-2 products on purified accessory cells.
March 1982, Immunology,
H von Boehmer, and C G Fathman, and W Haas
T helper cells, IL-2 and the generation of cytotoxic T-cell responses.
October 2002, Trends in immunology,
Copied contents to your clipboard!