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Changes in the structure and cell composition of carinal lymph nodes were studied in humans during aging. Replacement of node parenchyma with fibrous connective tissue progressing with age was demonstrated. The medullary matter significantly prevailed over the cortical substance. The lymph nodes in the cortical substance were small and had no light centers; the concentration of mature CD20+ B cells was high; the paracortical area was fragmented and thinned and contained no CD4+ T helpers. Ki-67+ cells were absent in all structural components of the lymph nodes reflecting exhaustion of lymphopoietic function, which was determined by the replacement of the reticular tissue of the microenvironment with the connective tissue and by the absence of CD4+ T cells regulating cellular and humoral immunity. The disintegration of the reticular stroma in the sinus system that acts as a biological filter impairs the function of lymph purification.
L M Erofeeva, and
M V Mnikhovich
August 1984,
Arkhiv anatomii, gistologii i embriologii,
L M Erofeeva, and
M V Mnikhovich
November 2000,
Clinical radiology,
L M Erofeeva, and
M V Mnikhovich
January 2008,
Lymphatic research and biology,
L M Erofeeva, and
M V Mnikhovich
October 1988,
Arkhiv anatomii, gistologii i embriologii,
L M Erofeeva, and
M V Mnikhovich
January 1970,
Arkhiv patologii,
L M Erofeeva, and
M V Mnikhovich
August 1988,
Arkhiv anatomii, gistologii i embriologii,
L M Erofeeva, and
M V Mnikhovich
November 1973,
Arkhiv anatomii, gistologii i embriologii,
L M Erofeeva, and
M V Mnikhovich
December 1984,
The Journal of pathology,
L M Erofeeva, and
M V Mnikhovich
January 2013,
Morfologiia (Saint Petersburg, Russia),
L M Erofeeva, and
M V Mnikhovich
February 2012,
Haematologica,
