Biomaterial Database

Elucidating the developmental trajectories of GABAergic cortical interneuron subtypes. 2019

Goichi Miyoshi

Department of Neurophysiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan. Electronic address: Goichi.Miyoshi@gmail.com.

GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to neurodevelopmental disorders. Very interestingly, a large diversity of morphology, synaptic targeting specificity, electrophysiological properties and molecular expression profiles are found in cortical interneurons, which originate within the distantly located embryonic ganglionic eminences. Here, I will review the still ongoing effort to understand the developmental trajectories of GABAergic cortical interneuron subtypes.

UI	MeSH Term	Description	Entries
D007395	Interneurons	Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.	Intercalated Neurons,Intercalated Neuron,Interneuron,Neuron, Intercalated,Neurons, Intercalated
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D055495	Neurogenesis	Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.	Neurogeneses
D059330	GABAergic Neurons	Neurons whose primary neurotransmitter is GAMMA-AMINOBUTYRIC ACID.	GABA Cells,GABA Neurons,Cell, GABA,Cells, GABA,GABA Cell,GABA Neuron,GABAergic Neuron,Neuron, GABA,Neuron, GABAergic,Neurons, GABA,Neurons, GABAergic
D018507	Gene Expression Regulation, Developmental	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.	Developmental Gene Expression Regulation,Embryologic Gene Expression Regulation,Gene Expression Regulation, Embryologic,Regulation of Gene Expression, Developmental,Regulation of Gene Expression, Embryologic,Regulation, Gene Expression, Developmental,Regulation, Gene Expression, Embryologic
D019579	Neocortex	The largest portion of the CEREBRAL CORTEX in which the NEURONS are arranged in six layers in the mammalian brain: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multiform layers.	Cerebral Neocortex,External Granular Layer,Isocortex,Neocortical External Granular Layer,Neocortical External Pyramidal Layer,Neocortical Internal Granular Layer,Neocortical Internal Pyramidal Layer,Neocortical Molecular Layer,Neocortical Multiform Layer,Neopallial Cortex,Neopallium,Substantia Corticalis,Cerebral Neocortices,Cortex, Neopallial,Corticali, Substantia,Corticalis, Substantia,Cortices, Neopallial,External Granular Layers,Granular Layer, External,Granular Layers, External,Isocortices,Layer, External Granular,Layer, Neocortical Molecular,Layer, Neocortical Multiform,Layers, External Granular,Layers, Neocortical Molecular,Layers, Neocortical Multiform,Molecular Layer, Neocortical,Molecular Layers, Neocortical,Multiform Layer, Neocortical,Multiform Layers, Neocortical,Neocortex, Cerebral,Neocortical Molecular Layers,Neocortical Multiform Layers,Neocortices,Neocortices, Cerebral,Neopallial Cortices,Neopalliums,Substantia Corticali