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Antibody against actin isolated from a human EBV-transformed lymphoblastoid B-cell line exerted an inhibitory effect on in vitro IgM secretion by a different lymphoblastoid B-cell line, LA350. This effect was dose dependent showing from 24-40% inhibition at a dilution of 1:100 and 68-80% inhibition at a dilution of 1:50. This effect was noted in the absence of changes in either total cell count or [3H]-thymidine incorporation and was reversed by co-incubation with purified rabbit thymus actin (100 micrograms/ml) but not bovine serum albumin at the same concentration. These data demonstrate regulation of immunoglobulin synthesis by antibodies against human lymphocyte derived actin in a lymphoblastoid B-cell line.
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
February 1997,
In vitro cellular & developmental biology. Animal,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
May 1984,
Journal of immunological methods,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
October 1982,
Medical biology,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
April 1992,
Journal of virological methods,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
January 1992,
International journal of clinical & laboratory research,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
October 1992,
European journal of clinical investigation,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
August 1989,
Hybridoma,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
January 1994,
Human antibodies and hybridomas,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
January 1990,
Clinical immunology and immunopathology,
H M Rosenblatt, and
C G Green, and
J E McClure, and
W T Shearer
April 1987,
Journal of immunology (Baltimore, Md. : 1950),
