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Expression of blood group ABH, Lewis, and sialylated-Lea antigens in human hepatocellular carcinomas and the adjacent nontumorous liver tissues was investigated with the use of seven monoclonal antibodies against these carbohydrate determinants. Chromatogram antibody-binding assay and solid-phase enzyme immunoassay of the upper-phase neutral glycolipids revealed the tumor-associated expression of blood group A-active glycolipids incompatible with blood-type status of the patients, a blood group A-active glycolipid with mobility on thin-layer chromatography between the known 6- and 8-sugar blood group A-active glycolipids in human erythrocytes, blood group H-active glycolipids, and blocked synthesis of Lea-active glycolipids with or without concomitant accumulation of Leb-active glycolipids. Immunohistochemical analysis of the fixed tissues with the use of an avidin-biotin-peroxidase complex method revealed blood group antigens in biliary epithelial cells but not in parenchymal liver cells. However, hepatocellular carcinoma cells in some cases expressed H and Leb antigens. Although only type 1 chain H antigen was detected in biliary epithelial cells, both type 1 and type 2 chain H antigens were found in hepatocellular carcinoma cells.
Y Okada, and
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S Moriwaki, and
T Kunitomo, and
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APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
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T Arima, and
K Togawa, and
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S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
January 1988,
American journal of reproductive immunology and microbiology : AJRIM,
Y Okada, and
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K Togawa, and
H Nagashima, and
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S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
January 1983,
Biochimica et biophysica acta,
Y Okada, and
T Arima, and
K Togawa, and
H Nagashima, and
K Jinno, and
S Moriwaki, and
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H Koprowski
January 1998,
Romanian journal of physiology : physiological sciences,
Y Okada, and
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K Togawa, and
H Nagashima, and
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S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
March 1994,
Investigative ophthalmology & visual science,
Y Okada, and
T Arima, and
K Togawa, and
H Nagashima, and
K Jinno, and
S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
April 1978,
European journal of biochemistry,
Y Okada, and
T Arima, and
K Togawa, and
H Nagashima, and
K Jinno, and
S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
October 2006,
Archives of medical research,
Y Okada, and
T Arima, and
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K Jinno, and
S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
July 1993,
Cancer,
Y Okada, and
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K Togawa, and
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T Kunitomo, and
J Thurin, and
H Koprowski
October 1970,
Chemistry and physics of lipids,
Y Okada, and
T Arima, and
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H Nagashima, and
K Jinno, and
S Moriwaki, and
T Kunitomo, and
J Thurin, and
H Koprowski
March 1987,
Cancer research,
