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The present study was conducted to characterize the in vivo effects of epinephrine administration on levels of pituitary cyclic AMP and plasma hormones. Rats were injected with saline or epinephrine bitartrate (1 mg/kg lP) and sacrificed by decapitation 1, 5, 15, 30 or 60 min post-injection. Levels of pituitary cyclic AMP and plasma ACTH, beta-endorphin, beta-LPH, corticosterone and prolactin were determined by radioimmunoassays. The injection procedure itself was somewhat stressful as demonstrated by increased levels of plasma prolactin and ACTH 5 min following either saline or epinephrine injection. This "stress" response was rapid and short-lasting for the pituitary hormones. The response of the adrenal hormone, corticosterone, to saline injection was slower in onset and longer in duration. Pituitary cyclic AMP levels did not increase following saline injection. Epinephrine-injected animals displayed markedly elevated plasma levels of ACTH, beta-endorphin and beta-LPH at 15, 30 and 60 min as compared to control or saline-injected rats. In addition, levels of pituitary cyclic AMP were increased over 10 fold at these times. Levels of plasma prolactin, a stress-responsive hormone, were not significantly increased in epinephrine-injected animals as compared to saline-injected rats indicating that these later responses seem to be specific to epinephrine rather than to stress.
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
August 1988,
Science (New York, N.Y.),
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
October 1962,
Biochemical and biophysical research communications,
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
July 1981,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
March 1975,
Archives of surgery (Chicago, Ill. : 1960),
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
November 1982,
Pharmacology, biochemistry, and behavior,
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
July 1978,
The American journal of physiology,
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
March 1991,
Acta paediatrica Scandinavica,
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
January 1984,
Headache,
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
May 1984,
Clinical science (London, England : 1979),
E H Mougey, and
J L Meyerhoff, and
L L Pennington, and
C C Kenion, and
G J Kant
October 1975,
FEBS letters,
