Novel combination proliposomes containing tobramycin and clarithromycin effective against Pseudomonas aeruginosa biofilms. 2018

Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wen hua Road, Shenyang 110016, China.

Tobramycin (TOB) and clarithromycin (CLA) can potentially be used synergistically for the treatment of respiratory infections caused by Pseudomonas aeruginosa (P. aeruginosa) in cystic fibrosis (CF) patients. This study aimed to develop a novel combination proliposome formulation (TOB/CLA-CPROLips) containing both hydrophilic TOB and hydrophobic CLA via a core-carrier approach. The combination proliposomes were produced by spray drying a suspension comprising spray-driedmannitol (SD-MAN, 0.45%) and spray-dried tobramycin (SD-TOB, 0.05%) particles suspended in an ethanolic lipid solution of CLA (0.05%). The lipid layer coated on the surface of the dry proliposome particles conferred moisture protection and sustained drug release properties in comparison to the pure drugs. The optimized TOB/CLA-CPROLips formulation was stable after 3 months of storage at 60% relative humidity (RH) and 25 °C. The combination drug proliposomes showed a synergistic antimicrobial activity against planktonic cells and biofilm cultures of P. aeruginosa. In conclusion, the core-carrier method coupled with spray-drying provided a novel approach for the preparation of combination antibiotics proliposomes.

UI MeSH Term Description Entries
D008081 Liposomes Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins. Niosomes,Transferosomes,Ultradeformable Liposomes,Liposomes, Ultra-deformable,Liposome,Liposome, Ultra-deformable,Liposome, Ultradeformable,Liposomes, Ultra deformable,Liposomes, Ultradeformable,Niosome,Transferosome,Ultra-deformable Liposome,Ultra-deformable Liposomes,Ultradeformable Liposome
D011550 Pseudomonas aeruginosa A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection. Bacillus aeruginosus,Bacillus pyocyaneus,Bacterium aeruginosum,Bacterium pyocyaneum,Micrococcus pyocyaneus,Pseudomonas polycolor,Pseudomonas pyocyanea
D003890 Desiccation Removal of moisture from a substance (chemical, food, tissue, etc.). Dessication
D004338 Drug Combinations Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture. Drug Combination,Combination, Drug,Combinations, Drug
D004339 Drug Compounding The preparation, mixing, and assembly of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814). Drug Formulation,Drug Preparation,Drug Microencapsulation,Pharmaceutical Formulation,Compounding, Drug,Formulation, Drug,Formulation, Pharmaceutical,Microencapsulation, Drug,Preparation, Drug
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D014031 Tobramycin An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species. Nebramycin Factor 6,Brulamycin,Nebcin,Nebicin,Obracin,Tobracin,Tobramycin Sulfate,Sulfate, Tobramycin
D017291 Clarithromycin A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation. 6-O-Methylerythromycin,A-56268,Biaxin,TE-031,A 56268,A56268,TE 031,TE031
D018441 Biofilms Encrustations formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedded in an EXTRACELLULAR POLYMERIC SUBSTANCE MATRIX that is secreted by the microbes. They occur on body surfaces such as teeth (DENTAL DEPOSITS); inanimate objects, and bodies of water. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and anti-fouling agents. Biofilm
D065546 Drug Liberation Release of drugs from DOSAGE FORMS into solution. Drug Dissolution,Drug Release,Dissolution, Drug,Liberation, Drug,Release, Drug

Related Publications

Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
November 2017, Antimicrobial agents and chemotherapy,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
June 2011, Antimicrobial agents and chemotherapy,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
July 2020, Pharmaceutics,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
January 2000, Chemotherapy,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
January 2019, Frontiers in microbiology,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
September 1993, Antimicrobial agents and chemotherapy,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
January 2018, Pharmaceutical research,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
July 2015, International journal of antimicrobial agents,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
August 2007, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
Tiantian Ye, and Siping Sun, and Tiffanie Daisy Sugianto, and Patricia Tang, and Thaigarajan Parumasivam, and Yoon Kyung Chang, and Ariel Astudillo, and Shujun Wang, and Hak-Kim Chan
August 2022, Drug delivery and translational research,
Copied contents to your clipboard!