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An assay system for the measurement of the rate of Calcium Oxalate Monohydrate (COM) seed crystal growth in a metastable solution of calcium chloride and sodium oxalate containing traces of 14C-oxalic acid was used to assess the inhibitory activity of pyrophosphate (10(-5) M-10(-4) M), citrate (10(-4) M-10(-3) M) and urines of normal and pyridoxine deficient rats. Both pyrophosphate and citrate were strong inhibitors of COM crystal growth and caused a 50% decrease in crystal growth rate at 1.50 X 10(-5) M and 2.85 X 10(-4) M respectively. Normal rat urine strongly inhibited the COM crystal growth, while pyridoxine deficient animals showed a significant (p less than 0.01) decrease in mean inhibitory activity as compared to pair-fed controls. A lowered urinary inhibitory potential accompanied with hyperoxaluria and hypercalciuria, which is known to be associated with pyridoxine deficiency, may be a contributory risk of calcium oxalate crystallization and stone formation.
H Sidhu, and
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R Nath
July 1989,
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H Sidhu, and
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H Sidhu, and
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H Sidhu, and
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February 1988,
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H Sidhu, and
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R Nath
January 1990,
Urological research,
H Sidhu, and
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R Nath
January 2011,
Cells, tissues, organs,
H Sidhu, and
R Gupta, and
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R Nath
March 1990,
Scanning microscopy,
H Sidhu, and
R Gupta, and
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R Nath
January 1996,
Urological research,
H Sidhu, and
R Gupta, and
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R Nath
January 1993,
Urological research,
H Sidhu, and
R Gupta, and
S K Thind, and
R Nath
October 1983,
The Journal of biological chemistry,
