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To test the hypothesis that the trophic action of angiotensin II on the adrenal zona glomerulosa may allow a sustained stimulation of aldosterone by ACTH by preventing the morphological changes of the zona glomerulosa cells into zona fasciculata-like elements we investigated the effects in rats of a 6-day treatment with ACTH (100 micrograms/kg/day) alone or combined with angiotensin II (300 ng/kg/day) on corticosterone and aldosterone production and adrenal morphology. The responsiveness of both steroids to an acute ACTH dose was also studied on the last day of long-term treatment. Morphologic data showed that prolonged ACTH treatment stimulated the growth of zona glomerulosa cells, though it transformed the tubulo-lamellar cristae of mitochondria into a homogeneous population of vesicles. Angiotensin II furthered the trophic effects of ACTH but prevented the mitochondrial transformation. Despite its ability to conserve the well differentiated aspect of the zona glomerulosa cells, the administration of angiotensin II was unable to prevent the fall in the secretion of aldosterone caused by chronic ACTH treatment and its subsequent unresponsiveness to ACTH stimulation.
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
December 1986,
Experimental and clinical endocrinology,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
October 1984,
Experimental and clinical endocrinology,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
January 1985,
Acta endocrinologica,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
January 1986,
Cell and tissue research,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
November 1981,
The Journal of biological chemistry,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
March 1985,
Endocrinology,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
October 1974,
Endocrinology,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
September 1977,
Clinical science and molecular medicine,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
November 1996,
Endocrine research,
A M Riondel, and
P Rebuffat, and
G Mazzochi, and
G G Nussdorfer, and
R C Gaillard, and
L Bockhorn, and
J Nussberger, and
M B Vallotton, and
A F Muller
November 1996,
Endocrine research,
