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The effects of alpha 2-adrenergic-receptor blocker mianserin on the responses of blood glucose, plasma beta-thromboglobulin (beta-TG), and various counterregulatory hormones to insulin-induced hypoglycemia were studied in nine healthy male subjects. The alpha 2-adrenoceptor-blocking action of mianserin was confirmed by its inhibitory effect on platelet activation in vitro. Mianserin was given orally 90 min before insulin injection; the same study without mianserin was performed on another day as the control study. The time courses of blood glucose and serum C-peptide (0, 20, 45, and 180 min after the insulin injection) were identical in both studies, indicating that mianserin has no effect on these parameters. However, a significant increase of beta-TG at 45 min after insulin injection was completely suppressed by the administration of mianserin (mean +/- SE, 68.5 +/- 6.0 vs. 28.8 +/- 7.6 ng/ml, n = 6, P less than .05). No significant differences were obtained between the two studies in the responses of plasma or serum catecholamines, cortisol, glucagon, growth hormone, thromboxane B2, and 6-ketoprostaglandin F1 alpha. These results suggest that epinephrine is responsible for some, if not all, of the beta-TG release from the platelets during insulin-induced hypoglycemia.
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
January 1988,
Journal of psychosomatic research,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
September 1988,
The Journal of clinical endocrinology and metabolism,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
April 1991,
Clinical pharmacology and therapeutics,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
January 1977,
European journal of pharmacology,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
January 1993,
The Journal of laboratory and clinical medicine,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
September 1984,
Neuroendocrinology,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
November 1998,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
October 1970,
Diabetes,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
March 1968,
Diabetes,
H Kishikawa, and
H Takeda, and
S Kiyota, and
M Sakakida, and
H Fukushima, and
K Ichinose, and
H Matsuda, and
N Nakamura, and
H Uzawa
January 1988,
Psychiatry research,
