-transparent.png){kind=logo}
Thirty surgical samples of squamous cell carcinoma of the cervix obtained from Chinese women were analysed for the presence of human papillomavirus (HPV) types 16 and 18 using Southern blot hybridization procedure. HPV16 was detected in 53% while HPV18 was found in only 6% of the samples analyzed. When compared with other reports, variation in the geographic distribution of these two HPV types in association with cervical carcinoma is noted. Thirty-seven and a half percent of the HPV16-positive samples contained this HPV type in episomal form and an equal number in cellular DNA-integrated form. The simultaneous presence of both episomal and integrated forms was found in the remaining 25% of the positive samples. The two HPV18-positive cases harbored only episomal viral genome and were not superinfected by HPV16. Analysis of the HPV16 integration samples showed that single integration events had probably occurred and some of the viral sequences had been lost on or subsequent to integration.
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
September 1983,
British medical journal (Clinical research ed.),
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
June 1985,
The American journal of pathology,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
October 1997,
Virus research,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
March 1988,
Asia-Oceania journal of obstetrics and gynaecology,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
December 1991,
Journal of clinical pathology,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
July 1980,
Nature,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
September 1989,
Virology,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
October 1988,
Journal of medical virology,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
January 1985,
Nature,
K B Choo, and
C C Pan, and
M S Liu, and
H T Ng, and
C P Chen, and
Y N Lee, and
C F Chao, and
C L Meng, and
M Y Yeh, and
S H Han
February 1990,
Journal of virology,
