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This unit describes an effective method for the preparation of natural cytokinins and their synthetic derivatives based on enzymatic cleavage of the N-glycosidic bond of N6 -substituted adenosine or O6 -substituted inosine derivatives in the presence of purine nucleoside phosphorylase (PNP) and Na2 HAsO4 . The arsenolysis reaction is irreversible due to the hydrolysis of the resulting α-D-ribose-1-arsenate. As a result, the desired products are formed in near-quantitative yields, as indicated by high-performance liquid chromatography (HPLC) analysis, and can easily be isolated. In the strategy used here, the ribose residue acts as a protective group. © 2018 by John Wiley & Sons, Inc.
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
June 1972,
Journal of the American Chemical Society,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
April 2019,
Chemical biology & drug design,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
October 2007,
The Journal of organic chemistry,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
January 2004,
Nucleic acids symposium series (2004),
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
May 2016,
Organic & biomolecular chemistry,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
February 2000,
Organic letters,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
January 2006,
Nucleosides, nucleotides & nucleic acids,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
July 2004,
Organic letters,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
June 1972,
Journal of molecular biology,
Vladimir E Oslovsky, and
Mikhail S Drenichev, and
Cyril S Alexeev, and
Pavel N Solyev, and
Roman S Esipov, and
Sergey N Mikhailov
July 1955,
The Journal of biological chemistry,
