-transparent.png){kind=logo}
The activity and mode of action of the new nucleoside analog (RS)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) against varicella-zoster virus (VZV) were determined. In cell culture, replication of different strains of VZV was inhibited to 50% by 0.4 to 0.7 microM 2HM-HBG, while 685 microM was required to inhibit 50% of the DNA synthesis in uninfected human lung fibroblasts. A thymidine kinase-negative VZV strain was not inhibited by 100 microM 2HM-HBG. Inhibition of VZV replication was not reversible after 7 to 14 days of incubation, depending on the multiplicity of VZV. 2HM-HBG was shown to be selectively phosphorylated by purified VZV thymidine kinase, with an inhibition constant of 32.5 microM. The antiviral activity of 2HM-HBG in cell culture was decreased by the addition of deoxythymidine and deoxycytidine but not by other ribo- or deoxyribonucleosides.
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
August 1988,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
December 1988,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
June 1993,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
June 2001,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
January 1989,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
August 1995,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
December 1990,
Antimicrobial agents and chemotherapy,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
September 2009,
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
July 1983,
Proceedings of the National Academy of Sciences of the United States of America,
G Abele, and
A Karlström, and
J Harmenberg, and
S Shigeta, and
A Larsson, and
B Lindborg, and
B Wahren
August 2009,
Biomedical chromatography : BMC,
