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We studied pseudorabies virus-induced ribonucleotide reductase and found that it exhibited biochemical properties very similar to those of herpes simplex virus reductase. A polyclonal rabbit antiserum (P9) directed against the carboxy terminus of subunit H2 polypeptide (38,000 daltons) of herpes simplex virus reductase neutralized the pseudorabies virus reductase, as well as the herpes simplex virus isozyme. This serum recognized two pseudorabies virus-specified polypeptides of 34,000 and 110,000 daltons, which may represent the two subunits of the enzyme. Furthermore, as already shown for herpes simplex virus reductase (E. A. Cohen, P. Gaudreau, P. Brazeau, and Y. Langelier, Nature [London] 321:441-443, 1986), we show that the nonapeptide itself specifically inhibited pseudorabies reductase activity.
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
July 2020,
Veterinary microbiology,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
February 1984,
Journal of virology,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
March 1982,
Journal of virology,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
January 2009,
Trends in biochemical sciences,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
March 1993,
The Journal of general virology,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
June 1976,
Biochemical and biophysical research communications,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
June 2013,
Avian diseases,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
August 2020,
Antiviral research,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
June 1996,
Journal of virology,
E A Cohen, and
H Paradis, and
P Gaudreau, and
P Brazeau, and
Y Langelier
November 1994,
Virology,
