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Brachyspira hyodysenteriae (Bhyo) induces mucohemorrhagic diarrhea in pigs and is an economically significant disease worldwide. Our objectives were to determine the impact of Bhyo on apparent total tract digestibility (ATTD), ileal digestibility (AID), and ileal basal endogenous losses (BEL) in grower pigs. In addition, we assessed the effect of Bhyo on hindgut disappearance of DM, N, and GE. Thirty-two Bhyo negative gilts (38.6 ± 0.70 kg BW) were fitted with a T-cannula in the distal ileum and individually penned. In replicates 1 and 2, pigs were fed a complete diet (7 Bhyo-, 10 Bhyo+ pigs) or nitrogen-free diet (NFD; 4 Bhyo-, 11 Bhyo+ pigs), respectively. Across multiple rooms, the 21 Bhyo+ pigs (62.6 ± 1.39 kg BW) were inoculated with Bhyo on day post inoculation (dpi) 0, and the 11 Bhyo- pigs were sham inoculated. Feces were collected from 9 to 11 dpi and ileal digesta collected from 12 to 13 dpi. All pigs were euthanized at 14 to 15 dpi and intestinal tract pathology assessed. Within the complete diet and NFD treatments, data were analyzed to determine pathogen effects. All Bhyo- pigs remained Bhyo negative, and 5 Bhyo+ pigs in each replicate were confirmed Bhyo positive within 9 dpi. Infection with Bhyo reduced ATTD of DM, N, and GE and increased AID of Gly (P < 0.05). No other AA AID differences were observed. Only BEL of Pro was reduced (P < 0.05) while Arg, Trp, and Gly tended (P < 0.10) to be reduced in Bhyo+ pigs. When calculated from AID and BEL, Bhyo infection reduced standardized ileal digestibility (SID) of N, Arg, Lys, Ala, Gly, Pro, and Ser (P < 0.05) and tended to reduce Thr SID (P = 0.09). In the hindgut of Bhyo+ pigs, there was generally an appearance of nutrients rather than disappearance. In Bhyo+ pigs fed a complete diet, hindgut appearance of N and GE were increased (P < 0.05) by 58 and nine-fold, respectively, and DM tended to be increased two-fold (P = 0.06). Similarly, in NFD fed pigs, hindgut appearance of N and GE was increased by 172% and 162%, respectively, although high variability led to no significance. Altogether, Bhyo infection decreases ATTD but has minimal impact on AID of AA, when corrected for BEL, SID of N, Arg, Lys and some nonessential AA are specifically reduced. Unexpectedly, BEL of several AA involved in mucin production were unaffected by Bhyo infection. This may suggest an increased need for specific AA and energy during a Bhyo challenge.
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
December 2004,
Journal of animal science,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
June 2016,
Animal nutrition (Zhongguo xu mu shou yi xue hui),
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
February 2005,
Veterinary microbiology,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
June 2006,
Journal of animal science,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
March 2009,
Veterinary microbiology,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
January 2019,
F1000Research,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
February 2023,
Microbial pathogenesis,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
March 1982,
The Veterinary record,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
November 1998,
The Journal of nutrition,
Wesley P Schweer, and
Eric R Burrough, and
John F Patience, and
Brian J Kerr, and
Nicholas K Gabler
January 2018,
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc,
