-transparent.png){kind=logo}
To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients' response to treatment.
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
January 1979,
Acta endocrinologica,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
November 1981,
Thorax,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
October 1977,
Diabetes,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
January 1984,
Cancer,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
March 1990,
Blut,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
October 1983,
Bulletin of the Osaka Medical School,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
January 1961,
The Journal of the Albert Einstein Medical Center, Philadelphia,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
October 1981,
Experimental cell research,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
May 1987,
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics,
M Peracchi, and
V Toschi, and
F Bamonti-Catena, and
L Lombardi, and
B Bareggi, and
A Cortelezzi, and
M Colombi, and
A T Maiolo, and
E E Polli
May 1976,
Biochimica et biophysica acta,
